The immunomodulatory activity of degradation products of Sesbania cannabina galactomannan with different molecular weights.

Galactose / analogs & derivatives Mannans / chemistry Molecular Weight Sesbania / chemistry
Galactomannan Hydroxyl group Toll-like receptor 4

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
30 Apr 2022
Historique:
received: 11 08 2021
revised: 10 01 2022
accepted: 18 02 2022
pubmed: 27 2 2022
medline: 7 4 2022
entrez: 26 2 2022
Statut: ppublish

Résumé

Galactomannan (GM) is widely recognized as an immune enhancer; however, the underlying molecular mechanism is still unknown. Herein, four products with molecular weights in descending order, namely GM40, GM50, GM65, and GMOS, were separated from incomplete degradation products of Sesbania cannabina GM by ethanol precipitation, followed by their immunomodulatory activity. Through FTIR and XPS spectra, the amount of free hydroxyl groups was shown to decrease in the following order: GM > GM50 > GMOS > GM40 > GM65. Moreover, the immunomodulatory activity of different products decreased in abovementioned order. The TNF-α, IL-6 and TLR4 content in RAW 264.7 cells treated with different GM products in the presence or absence of TAK-242 (TLR4 inhibitor) suggested that the immunomodulatory activity of GM and its degradation products is TLR4-dependent. Overall, the preliminary relationship indicated here between the hydroxyl groups or the possible deeper structural changes of GM and the immunomodulatory activity need to be further investigated.

Identifiants

DOI: 10.1016/j.ijbiomac.2022.02.122 PMID: 35217078
pubmed: 35217078
pii: S0141-8130(22)00368-3
doi: 10.1016/j.ijbiomac.2022.02.122
pii:
doi:

Substances chimiques

Mannans 0
galactomannan 11078-30-1
Galactose X2RN3Q8DNE

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

530-538

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Yuheng Tao (Y)

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China; Key Laboratory of Forestry Genetics & Biotechnology of the Ministry of Education, Nanjing Forestry University, Nanjing 210037, People's Republic of China.

Junmei Ma (J)

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China.

Caoxing Huang (C)

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China; Key Laboratory of Forestry Genetics & Biotechnology of the Ministry of Education, Nanjing Forestry University, Nanjing 210037, People's Republic of China.

Chenhuan Lai (C)

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China; Key Laboratory of Forestry Genetics & Biotechnology of the Ministry of Education, Nanjing Forestry University, Nanjing 210037, People's Republic of China.

Zhe Ling (Z)

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China.

Qiang Yong (Q)

Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China; Key Laboratory of Forestry Genetics & Biotechnology of the Ministry of Education, Nanjing Forestry University, Nanjing 210037, People's Republic of China. Electronic address: swhx@njfu.com.cn.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Galactose › The immunomodulatory activity of degradation...
questionsmedicales.fr › Glucides › Polyosides › Mannanes › The immunomodulatory activity of degradation...
questionsmedicales.fr › Phénomènes chimiques › Masse moléculaire › The immunomodulatory activity of degradation...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Sesbania › The immunomodulatory activity of degradation...