Oral and Intestinal Bacterial Substances Associated with Disease Activities in Patients with Rheumatoid Arthritis: A Cross-Sectional Clinical Study.
Acute-Phase Proteins
/ metabolism
Aged
Arthritis, Rheumatoid
/ immunology
Autoantibodies
/ blood
Bacterial Load
Bacteroidaceae Infections
/ immunology
Biomarkers
/ metabolism
Carrier Proteins
/ metabolism
Cross-Sectional Studies
Dysbiosis
/ immunology
Female
Gastrointestinal Microbiome
Humans
Immunoglobulin A
/ metabolism
Lipopolysaccharides
/ metabolism
Male
Membrane Glycoproteins
/ metabolism
Middle Aged
Mouth
/ microbiology
Porphyromonas gingivalis
/ physiology
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
07
2021
revised:
19
01
2022
accepted:
27
01
2022
entrez:
28
2
2022
pubmed:
1
3
2022
medline:
1
4
2022
Statut:
epublish
Résumé
Intestinal bacterial compositions of rheumatoid arthritis (RA) patients have been reported to be different from those of healthy people. Dysbiosis, imbalance of the microbiota, is widely known to cause gut barrier damage, resulting in an influx of bacteria and their substances into host bloodstreams in animal studies. However, few studies have investigated the effect of bacterial substances on the pathophysiology of RA. In this study, eighty-seven active RA patients who had inadequate responses to conventional synthetic disease-modifying antirheumatic drugs or severe comorbidities were analyzed for correlations between many factors such as disease activities, disease biomarkers, intestinal bacterial counts, fecal and serum lipopolysaccharide (LPS), LPS-binding protein (LBP), endotoxin neutralizing capacity (ENC), and serum antibacterial substance IgG and IgA antibody levels by multiple regression analysis with consideration for demographic factors such as age, sex, smoking, and methotrexate treatment. Serum LBP levels, fecal LPS levels, total bacteria counts, serum anti-LPS from
Identifiants
pubmed: 35224112
doi: 10.1155/2022/6839356
pmc: PMC8881124
doi:
Substances chimiques
Acute-Phase Proteins
0
Autoantibodies
0
Biomarkers
0
Carrier Proteins
0
Immunoglobulin A
0
Lipopolysaccharides
0
Membrane Glycoproteins
0
lipopolysaccharide-binding protein
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6839356Informations de copyright
Copyright © 2022 Kaori Kitamura et al.
Déclaration de conflit d'intérêts
KaK, SS, and HS declare that they received salary support from Asama Chemical Co. Ltd. KoK, SU, and CA declare that they were supported by their own respective clinics. HT and KN declare that they were supported by Aomori Prefectural Central Hospital and Teikyo University School of Medicine, respectively. HB and RK declare that they received salary support from Ayumi Pharmaceutical Co. Ltd. and Fukai Pharmacy, respectively. TW and KT declare that they received salary support from Chondrex, Inc.
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