Model to predict on-treatment restoration of functional HBV-specific CD8
HBV-specific CD8+ cell response
Nucleos(t)ide analogue
T-cell exhaustion
anti-viral therapy discontinuation
functional cure
predictive multivariate logistic regression model
Journal
Alimentary pharmacology & therapeutics
ISSN: 1365-2036
Titre abrégé: Aliment Pharmacol Ther
Pays: England
ID NLM: 8707234
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
12
10
2022
received:
12
09
2021
accepted:
14
02
2022
pubmed:
1
3
2022
medline:
27
5
2022
entrez:
28
2
2022
Statut:
ppublish
Résumé
Hepatitis B virus (HBV)-specific CD8 To predict this response with variables involved in T-cell exhaustion for use as a treatment stopping tool. In NUC-treated CHBe(-) patients, we considered a functional response in cases with HBV-specific CD8 We developed an LRM that predicted the presence of a proliferative type I cytokine-secreting CD8 Short-term low-level antigen exposure and early long-term NUC treatment influence the restoration of a functional HBV-specific CD8
Sections du résumé
BACKGROUND
Hepatitis B virus (HBV)-specific CD8
AIM
To predict this response with variables involved in T-cell exhaustion for use as a treatment stopping tool.
METHODS
In NUC-treated CHBe(-) patients, we considered a functional response in cases with HBV-specific CD8
RESULTS
We developed an LRM that predicted the presence of a proliferative type I cytokine-secreting CD8
CONCLUSIONS
Short-term low-level antigen exposure and early long-term NUC treatment influence the restoration of a functional HBV-specific CD8
Identifiants
pubmed: 35224746
doi: 10.1111/apt.16850
pmc: PMC9305412
doi:
Substances chimiques
Antiviral Agents
0
Cytokines
0
DNA, Viral
0
Epitopes
0
Hepatitis B Surface Antigens
0
Hepatitis B e Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1545-1559Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.
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