Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract.

Acetylcholine / pharmacology Adrenergic Agents Cardiac Electrophysiology Cholinergic Agents Electrocardiography Female Heart Ventricles Human Rights Humans Isoproterenol / pharmacology Male Pericardium Tachycardia, Ventricular / etiology Ventricular Premature Complexes
acetylcholine arrhythmias, cardiac heart ventricles isoproterenol ventricular premature complexes

Journal

Circulation. Arrhythmia and electrophysiology
ISSN: 1941-3084
Titre abrégé: Circ Arrhythm Electrophysiol
Pays: United States
ID NLM: 101474365

Informations de publication

Date de publication:
03 2022
Historique:
pubmed: 4 3 2022
medline: 4 5 2022
entrez: 3 3 2022
Statut: ppublish

Résumé

Right ventricular outflow tract (RVOT) is a common source of ventricular tachycardia, which often requires ablation. However, the mechanisms underlying the RVOT's unique arrhythmia susceptibility remain poorly understood due to lack of detailed electrophysiological and molecular studies of the human RVOT. We conducted optical mapping studies in 16 nondiseased donor human RVOT preparations subjected to pharmacologically induced adrenergic and cholinergic stimulation to evaluate susceptibility to arrhythmias and characterize arrhythmia dynamics. We found that under control conditions, RVOT has shorter action potential duration at 80% repolarization relative to the right ventricular apical region. Treatment with isoproterenol (100 nM) shortened action potential duration at 80% repolarization and increased incidence of premature ventricular contractions ( Human RVOT electrophysiology is characterized by shorter action potential duration relative to the right ventricular apical region. Cholinergic right ventricular stimulation attenuates the arrhythmogenic effects of adrenergic stimulation, including increase in frequency of premature ventricular contractions and shortening of wavelength. Right ventricular arrhythmia is characterized by positive spatial-temporal autocorrelation between epicardial-endocardial arrhythmic wave fronts and rotors that are relatively more organized in the endocardium.

Sections du résumé

BACKGROUND
Right ventricular outflow tract (RVOT) is a common source of ventricular tachycardia, which often requires ablation. However, the mechanisms underlying the RVOT's unique arrhythmia susceptibility remain poorly understood due to lack of detailed electrophysiological and molecular studies of the human RVOT.
METHODS
We conducted optical mapping studies in 16 nondiseased donor human RVOT preparations subjected to pharmacologically induced adrenergic and cholinergic stimulation to evaluate susceptibility to arrhythmias and characterize arrhythmia dynamics.
RESULTS
We found that under control conditions, RVOT has shorter action potential duration at 80% repolarization relative to the right ventricular apical region. Treatment with isoproterenol (100 nM) shortened action potential duration at 80% repolarization and increased incidence of premature ventricular contractions (
CONCLUSIONS
Human RVOT electrophysiology is characterized by shorter action potential duration relative to the right ventricular apical region. Cholinergic right ventricular stimulation attenuates the arrhythmogenic effects of adrenergic stimulation, including increase in frequency of premature ventricular contractions and shortening of wavelength. Right ventricular arrhythmia is characterized by positive spatial-temporal autocorrelation between epicardial-endocardial arrhythmic wave fronts and rotors that are relatively more organized in the endocardium.

Identifiants

DOI: 10.1161/CIRCEP.121.010630 PMID: 35238622 PMC: PMC9052172
pubmed: 35238622
doi: 10.1161/CIRCEP.121.010630
pmc: PMC9052172
mid: NIHMS1782067
doi:

Substances chimiques

Adrenergic Agents 0
Cholinergic Agents 0
Isoproterenol L628TT009W
Acetylcholine N9YNS0M02X

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e010630

Subventions

Organisme : NHLBI NIH HHS
ID : K99 HL148523
Pays : United States

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Auteurs

Kedar Aras (K)

Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
ORCID: 0000-0002-9898-1462

Anna Gams (A)

Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
ORCID: 0000-0002-3052-8469

Ndeye Rokhaya Faye (NR)

Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
Institut de rhythmologie et de modélisation cardiaque (LIRYC; The Rhythmology and Heart Modeling Institute), Bordeaux University, France (N.R.F., O.B.).
ORCID: 0000-0001-5695-7838

Jaclyn Brennan (J)

Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
ORCID: 0000-0002-0757-546X

Katherine Goldrick (K)

Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
ORCID: 0000-0002-2956-4606

Jinghua Li (J)

Department of Biomedical Engineering, Northwestern University, Evanston, IL (J.L., J.A.R.).
Department of Materials Science and Engineering, Ohio State University, Columbus, OH (J.L.).

Yishan Zhong (Y)

Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign (Y.Z.).
ORCID: 0000-0002-7010-4521

Chia-Han Chiang (CH)

Department of Biomedical Engineering, Duke University, Durham, NC (C.-H.C., J.V.).

Elizabeth H Smith (EH)

Department of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).
ORCID: 0000-0001-6037-2322

Megan D Poston (MD)

Department of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).
ORCID: 0000-0002-4842-7295

Jacqueline Chivers (J)

Department of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).

Peter Hanna (P)

University of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).
ORCID: 0000-0003-3092-5090

Shumpei Mori (S)

University of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).
ORCID: 0000-0002-5803-7135

Olujimi A Ajijola (OA)

University of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).
ORCID: 0000-0001-6197-7593

Kalyanam Shivkumar (K)

University of California at Los Angeles Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, University of California, Los Angeles (P.H., S.M., O.A.A., K.S.).
ORCID: 0000-0002-4121-1766

Donald B Hoover (DB)

Department of Biomedical Sciences, East Tennessee State University, Johnson City (E.H.S., M.D.P., J.C., D.B.H.).
ORCID: 0000-0002-0845-2488

Jonathan Viventi (J)

Department of Biomedical Engineering, Duke University, Durham, NC (C.-H.C., J.V.).
ORCID: 0000-0001-6054-0541

John A Rogers (JA)

Department of Biomedical Engineering, Northwestern University, Evanston, IL (J.L., J.A.R.).
ORCID: 0000-0002-2980-3961

Olivier Bernus (O)

Institut de rhythmologie et de modélisation cardiaque (LIRYC; The Rhythmology and Heart Modeling Institute), Bordeaux University, France (N.R.F., O.B.).
ORCID: 0000-0003-3917-5791

Igor R Efimov (IR)

Department of Biomedical Engineering, George Washington University, Washington, DC (K.A., A.G., N.R.F., J.B., K.G., I.R.E.).
ORCID: 0000-0002-1483-5039

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Professions de santé › Médecine › Médecine interne › Cardiologie › Électrophysiologie cardiaque › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrocardiographie › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Ventricules cardiaques › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Organisations et économie des soins de santé › Contrôle social formel › Droits de l'homme › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Isoprénaline › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › Tissus › Membranes › Séreuse › Péricarde › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Tachycardie › Tachycardie ventriculaire › Electrophysiology and Arrhythmogenesis in the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Extrasystoles › Extrasystoles ventriculaires › Electrophysiology and Arrhythmogenesis in the...