A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 03 2022
24 03 2022
Historique:
pubmed:
8
3
2022
medline:
7
5
2022
entrez:
7
3
2022
Statut:
ppublish
Résumé
Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of acetylcholinesterase located in the central nervous system and neuro-muscular junctions. One major drawback of these charged acetylcholinesterase reactivators is their poor ability to cross the blood-brain barrier. In this study, we propose to evaluate glucoconjugated oximes devoid of permanent charge as potential central nervous system reactivators. We determined their
Identifiants
pubmed: 35255209
doi: 10.1021/acs.jmedchem.1c01748
pmc: PMC8958973
doi:
Substances chimiques
Antidotes
0
Cholinesterase Inhibitors
0
Organophosphorus Compounds
0
Oximes
0
Sugars
0
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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