Pain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study.
function
haemophilia
pain
physical activity
prophylaxis
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
01
03
2022
received:
02
11
2021
accepted:
02
03
2022
pubmed:
9
3
2022
medline:
18
5
2022
entrez:
8
3
2022
Statut:
ppublish
Résumé
To establish the prevalence of pain and functional disability in Irish adults with moderate and severe haemophilia, and to examine demographic and lifestyle influences. Males ≥18 years with moderate or severe haemophilia participated. Pain and function were examined using the PROBE questionnaire. Of 49 participants [median age 44 (IQR 32, 52) years], most had severe haemophilia (Factor VIII = 30; Factor IX = 13) and were on regular prophylaxis (88%). Those with moderate haemophilia (Factor VIII = 5; Factor IX = 1) treated on demand (12%). Acute (72%) and chronic pain (71%), functional difficulties (58%), and analgesic requirements (92%) were prevalent. Age was significantly associated with more advanced haemophilic arthropathy (p = .002), chronic pain (p = .029) and functional difficulties (p = .036). Adults who reported chronic pain commenced prophylaxis significantly later in life [32 (20, 51) vs. 8 (1, 23) years; p = .004]. Physical activity was significantly lower in those with functional difficulties (p < .05). A disparity between self-perceived 'target joints' and clinically defined target joints was also identified (76% vs. 23%). Haemophilic arthropathy, pain and functional disability were prevalent amongst Irish adults with moderate and severe haemophilia. Age-dependent lifestyle, analgesic and treatment influences on pain and function warrant further investigation.
Identifiants
pubmed: 35258118
doi: 10.1111/ejh.13763
pmc: PMC9311204
doi:
Substances chimiques
Factor VIII
9001-27-8
Factor IX
9001-28-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
518-527Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Science Foundation Ireland
Pays : Ireland
Organisme : Takeda Pharmaceutical Company
Informations de copyright
© 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
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