A non-canonical tricarboxylic acid cycle underlies cellular identity.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
19
02
2021
accepted:
26
01
2022
pubmed:
11
3
2022
medline:
16
4
2022
entrez:
10
3
2022
Statut:
ppublish
Résumé
The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients to generate reducing equivalents for energy production and critical metabolites for biosynthetic reactions. Despite the importance of the products of the TCA cycle for cell viability and proliferation, mammalian cells display diversity in TCA-cycle activity
Identifiants
pubmed: 35264789
doi: 10.1038/s41586-022-04475-w
pii: 10.1038/s41586-022-04475-w
pmc: PMC8934290
mid: NIHMS1780333
doi:
Substances chimiques
Citric Acid
2968PHW8QP
ATP Citrate (pro-S)-Lyase
EC 2.3.3.8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-481Subventions
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NICHD NIH HHS
ID : F30 HD107943
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA252305
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA218679
Pays : United States
Organisme : NICHD NIH HHS
ID : F31 HD098824
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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