A non-canonical tricarboxylic acid cycle underlies cellular identity.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
03 2022
Historique:
received: 19 02 2021
accepted: 26 01 2022
pubmed: 11 3 2022
medline: 16 4 2022
entrez: 10 3 2022
Statut: ppublish

Résumé

The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients to generate reducing equivalents for energy production and critical metabolites for biosynthetic reactions. Despite the importance of the products of the TCA cycle for cell viability and proliferation, mammalian cells display diversity in TCA-cycle activity

Identifiants

pubmed: 35264789
doi: 10.1038/s41586-022-04475-w
pii: 10.1038/s41586-022-04475-w
pmc: PMC8934290
mid: NIHMS1780333
doi:

Substances chimiques

Citric Acid 2968PHW8QP
ATP Citrate (pro-S)-Lyase EC 2.3.3.8

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

477-481

Subventions

Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NICHD NIH HHS
ID : F30 HD107943
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA252305
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA218679
Pays : United States
Organisme : NICHD NIH HHS
ID : F31 HD098824
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Paige K Arnold (PK)

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, New York, NY, USA.

Benjamin T Jackson (BT)

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, New York, NY, USA.

Katrina I Paras (KI)

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA.

Julia S Brunner (JS)

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Madeleine L Hart (ML)

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Oliver J Newsom (OJ)

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Sydney P Alibeckoff (SP)

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Jennifer Endress (J)

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA.

Esther Drill (E)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lucas B Sullivan (LB)

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Lydia W S Finley (LWS)

Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. finleyl@mskcc.org.

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