Unspecific CTL Killing Is Enhanced by High Glucose


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 08 12 2021
accepted: 24 01 2022
entrez: 10 3 2022
pubmed: 11 3 2022
medline: 3 5 2022
Statut: epublish

Résumé

TNF-related apoptosis inducing ligand (TRAIL) is expressed on cytotoxic T lymphocytes (CTLs) and TRAIL is linked to progression of diabetes. However, the impact of high glucose on TRAIL expression and its related killing function in CTLs still remains largely elusive. Here, we report that TRAIL is substantially up-regulated in CTLs in environments with high glucose (HG) both

Identifiants

pubmed: 35265081
doi: 10.3389/fimmu.2022.831680
pmc: PMC8899024
doi:

Substances chimiques

Receptors, TNF-Related Apoptosis-Inducing Ligand 0
TNF-Related Apoptosis-Inducing Ligand 0
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

831680

Informations de copyright

Copyright © 2022 Yang, Denger, Diener, Küppers, Soriano-Baguet, Schäfer, Yanamandra, Zhao, Knörck, Schwarz, Hart, Lammert, Roma, Brenner, Christidis, Helms, Meese, Hoth and Qu.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Wenjuan Yang (W)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Andreas Denger (A)

Center for Bioinformatics, Saarland University, Saarbrücken, Germany.

Caroline Diener (C)

Institute of Human Genetics, School of Medicine, Saarland University, Homburg, Germany.

Frederic Küppers (F)

Internal Medicine II, University Hospital Saarland, Homburg, Germany.

Leticia Soriano-Baguet (L)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.
Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Gertrud Schäfer (G)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Archana K Yanamandra (AK)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
INM-Leibniz Institute for New Materials, Saarbrücken, Germany.

Renping Zhao (R)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Arne Knörck (A)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Eva C Schwarz (EC)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Martin Hart (M)

Institute of Human Genetics, School of Medicine, Saarland University, Homburg, Germany.

Frank Lammert (F)

Internal Medicine II, University Hospital Saarland, Homburg, Germany.
Hannover Medical School (MHH), Hannover, Germany.

Leticia Prates Roma (LP)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Dirk Brenner (D)

Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology and Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.
Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital University of Southern Denmark, Odense, Denmark.

Grigorios Christidis (G)

Internal Medicine II, University Hospital Saarland, Homburg, Germany.

Volkhard Helms (V)

Center for Bioinformatics, Saarland University, Saarbrücken, Germany.

Eckart Meese (E)

Institute of Human Genetics, School of Medicine, Saarland University, Homburg, Germany.

Markus Hoth (M)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.

Bin Qu (B)

Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
INM-Leibniz Institute for New Materials, Saarbrücken, Germany.

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Classifications MeSH