Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation.
Amino Acid Substitution
Animals
Calcium-Binding Proteins
/ antagonists & inhibitors
Cardiomyopathies
/ drug therapy
Disease Models, Animal
Female
Heart Function Tests
/ drug effects
Humans
Male
Mice
Oligonucleotides, Antisense
/ administration & dosage
Protein Aggregates
/ drug effects
Treatment Outcome
cardiomyopathy
gene therapy
genetic mutation
heart failure
phospholamban
protein aggregation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Feb 2022
22 Feb 2022
Historique:
received:
13
01
2022
revised:
16
02
2022
accepted:
21
02
2022
entrez:
10
3
2022
pubmed:
11
3
2022
medline:
26
3
2022
Statut:
epublish
Résumé
Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the phospholamban (
Identifiants
pubmed: 35269571
pii: ijms23052427
doi: 10.3390/ijms23052427
pmc: PMC8909937
pii:
doi:
Substances chimiques
Calcium-Binding Proteins
0
Oligonucleotides, Antisense
0
Protein Aggregates
0
phospholamban
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Netherlands Heart Institute
ID : 2020B005 (DCVA-DOUBLE-DOSE)
Organisme : Netherlands Heart Institute
ID : 2018-30 (CVON-PREDICT2)
Organisme : Netherlands Heart Institute
ID : 2017-21 (CVON-SHE-PREDICTS-HF)
Organisme : Netherlands Heart Institute
ID : 2017-11 (CVON-RED-CVD)
Organisme : Netherlands Heart Institute
ID : 2014-40 (CVON-DOSIS)
Organisme : Leducq Foundation
ID : Cure PhosphoLambaN-induced cardiomyopathy (CURE-PLaN)
Organisme : European Research Council
ID : Consolidator Grant (CoG) 818715 (SECRETE-HF)
Pays : International
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