A zirconium metal-organic framework with SOC topological net for catalytic peptide bond hydrolysis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 03 2022
11 03 2022
Historique:
received:
25
05
2021
accepted:
27
12
2021
entrez:
12
3
2022
pubmed:
13
3
2022
medline:
6
4
2022
Statut:
epublish
Résumé
The discovery of nanozymes for selective fragmentation of proteins would boost the emerging areas of modern proteomics, however, the development of efficient and reusable artificial catalysts for peptide bond hydrolysis is challenging. Here we report the catalytic properties of a zirconium metal-organic framework, MIP-201, in promoting peptide bond hydrolysis in a simple dipeptide, as well as in horse-heart myoglobin (Mb) protein that consists of 153 amino acids. We demonstrate that MIP-201 features excellent catalytic activity and selectivity, good tolerance toward reaction conditions covering a wide range of pH values, and importantly, exceptional recycling ability associated with easy regeneration process. Taking into account the catalytic performance of MIP-201 and its other advantages such as 6-connected Zr
Identifiants
pubmed: 35277474
doi: 10.1038/s41467-022-28886-5
pii: 10.1038/s41467-022-28886-5
pmc: PMC8917178
doi:
Substances chimiques
Metal-Organic Frameworks
0
Peptides
0
Zirconium
C6V6S92N3C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1284Informations de copyright
© 2022. The Author(s).
Références
Chem Soc Rev. 2020 Oct 19;49(20):7406-7427
pubmed: 32955065
Chem Soc Rev. 2016 Apr 21;45(8):2327-67
pubmed: 26886869
Nat Commun. 2018 Apr 25;9(1):1660
pubmed: 29695794
J Am Chem Soc. 2015 Oct 21;137(41):13308-18
pubmed: 26364990
Angew Chem Int Ed Engl. 2015 Jun 15;54(25):7391-4
pubmed: 25950869
J Am Chem Soc. 2018 May 23;140(20):6325-6335
pubmed: 29684281
J Am Chem Soc. 2018 Sep 12;140(36):11179-11183
pubmed: 30113833
Inorg Chem. 2012 Sep 17;51(18):9902-10
pubmed: 22928475
ChemSusChem. 2020 Apr 7;13(7):1710-1714
pubmed: 32026595
Chem Sci. 2019 Feb 28;10(14):3949-3955
pubmed: 31015934
Dalton Trans. 2016 Mar 14;45(10):4073-89
pubmed: 26537002
Chemistry. 2019 Nov 13;25(63):14370-14381
pubmed: 31469197
Chem Sci. 2020 May 22;11(26):6662-6669
pubmed: 34094124
J Am Chem Soc. 2014 Sep 17;136(37):12844-7
pubmed: 25157587
Inorg Chem. 2016 Sep 19;55(18):9316-28
pubmed: 27570876
J Am Chem Soc. 2013 Nov 13;135(45):17105-10
pubmed: 24125517
Inorg Chem. 2014 Jul 21;53(14):7086-8
pubmed: 25000271
Chemosphere. 2018 Oct;209:783-800
pubmed: 29960946
J Am Chem Soc. 2014 Mar 19;136(11):4369-81
pubmed: 24588307
Phys Chem Chem Phys. 2020 Nov 21;22(43):25136-25145
pubmed: 33118561
Nat Methods. 2019 Apr;16(4):319-322
pubmed: 30923372
J Am Chem Soc. 2020 Dec 23;142(51):21428-21438
pubmed: 33290083
Inorg Chem. 2015 May 18;54(10):4591-3
pubmed: 25908530
Nat Commun. 2018 May 1;9(1):1745
pubmed: 29717138
Chem Soc Rev. 2014 Aug 21;43(16):5618-56
pubmed: 24705653
Inorg Chem. 2015 Dec 7;54(23):11477-92
pubmed: 26599585
Nat Commun. 2014 Dec 04;5:5723
pubmed: 25474702
Angew Chem Int Ed Engl. 2020 Jun 2;59(23):9094-9101
pubmed: 32154631
Angew Chem Int Ed Engl. 2015 Jan 2;54(1):149-54
pubmed: 25385329