Mechanisms of the end-plate potential noise and its implication for the neuromuscular junction anatomy.
ACh receptor
Conductance noise
Seesaw effect
Journal
Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342
Informations de publication
Date de publication:
07 05 2022
07 05 2022
Historique:
received:
13
08
2021
revised:
25
01
2022
accepted:
03
03
2022
pubmed:
15
3
2022
medline:
6
4
2022
entrez:
14
3
2022
Statut:
ppublish
Résumé
We construct a compact model to mimic the membrane voltage response to the concentration of acetylcholine ([ACh]) which is mediated by the stochastic gating of acetylcholine (ACh) receptors. The patterns of the voltage depolarization against [ACh] as well as the accompanying voltage noises are presented. The mechanism of the voltage fluctuation that caused by the stochastic gating of receptors is explained. We consider that our results explain the frequently observed "end-plate (potential) noise" in physiology and electromyographic literature. These results, together with the requirements of evolution pressure on the motor units, explain reasonably the anatomical structure of the neuromuscular junction.
Identifiants
pubmed: 35283183
pii: S0022-5193(22)00087-X
doi: 10.1016/j.jtbi.2022.111089
pii:
doi:
Substances chimiques
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111089Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.