Gaining more insight into ankle pain in haemophilia: A study exploring pain, structural and functional evaluation of the ankle joint.
biopsychosocial
diagnostic imaging
haemophilia
joint diseases
pain
pressure pain threshold
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
25
02
2022
received:
30
11
2021
accepted:
25
02
2022
pubmed:
17
3
2022
medline:
14
5
2022
entrez:
16
3
2022
Statut:
ppublish
Résumé
Ankle arthropathy is highly prevalent among people with haemophilia (PwH), even with prophylaxis, and leads to pain and disability. Mechanisms and consequences of painful symptoms related to ankle arthropathy have not been extensively studied. A consecutive sample of 30 adult PwH was included (60 ankles). Ankle structure was assessed with magnetic resonance imaging (IPSG-MRI) and ultrasound (HEAD-US). The HJHS 2.1 assessed function of ankles and knees. Physical functioning was assessed with the Timed Up and Go test, the 2-Minute Walking Test and activity limitations with the HAL questionnaire. Health-related quality of life was evaluated using the EQ-5D-5L questionnaire. Overall pain severity was examined using the Brief Pain Inventory questionnaire and ankle pain intensity with a visual analogue scale. Pressure pain thresholds with an algometer assessed pain sensitivity. Spearman correlations were used to calculate interrelations between joint structure, function and pain. Twenty-five PwH (83%) reported ≥1 painful joint, with 67% reporting the ankle as most painful joint. MRI-confirmed abnormalities were seen in 76% of talocrural and 55% of subtalar joints. HEAD-US abnormalities were seen in 93% of the ankles. A large variation was seen in pain sensitivity at the ankle. While moderate to high correlations were observed between ankle structure and HJHS, no meaningful correlations were found between MRI-scores and pain intensity or sensitivity. Structural joint damage is present in many ankles but is not related to pain in PwH. Further studies should consider somatosensory nervous system dysfunction in PwH as contributing factor to painful ankle arthropathy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
480-490Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Pulles AE, Mastbergen SC, Schutgens REG, Lafeber F, Van Vulpen LFD. Pathophysiology of hemophilic arthropathy and potential targets for therapy. Pharmacol Res. 2017;115:192-199.
Kempton CL, Recht M, Neff A, et al. Impact of pain and functional impairment in US adults with haemophilia: patient-reported outcomes and musculoskeletal evaluation in the pain, functional impairment and quality of life (P-FiQ) study. Haemophilia. 2018;24(2):261-270.
Rambod M, Sharif F, Molazem Z, Khair K. Pain experience in hemophilia patients: a hermeneutic phenomenological study. Int J Community Based Nurs Midwifery. 2016;4(4):309-319.
Song SJ, Bae JK, Park CH, Yoo MC, Bae DK, Kim KI. Mid-term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: a review of consecutive 131 knees between 2006 and 2015 in a single institute. Haemophilia. 2018;24(2):299-306.
Cuesta-Barriuso R, Gómez-Conesa A, López-Pina JA. The effectiveness of manual therapy in addition to passive stretching exercises in the treatment of patients with haemophilic knee arthropathy: a randomized, single-blind clinical trial. Haemophilia. 2021;27(1):e110-e118.
Roussel NA. Gaining insight into the complexity of pain in patients with haemophilia. State of the art review on pain processing. Haemophilia. 2018;24:3-8.
Fillingim RB. Individual differences in pain: understanding the mosaic that makes pain personal. Pain. 2017;158 Suppl 1:S11-S18.
Roussel NA, Nijs J, Meeus M, Mylius V, Fayt C, Oostendorp R. Central sensitization and altered central pain processing in chronic low back pain: fact or myth? Clin J Pain. 2013;29(7):625-638.
Arendt-Nielsen L, Skou ST, Nielsen TA, Petersen KK. Altered central sensitization and pain modulation in the CNS in chronic joint pain. Curr Osteoporos Rep. 2015;13(4):225-234.
Merskey H, Bogduk N. Classification of Chronic Pain, Second Edition. IASP Task Force on Taxonomy. Seattle: IASP Press; 1994.
Meeus M, Roussel NA, Truijen S, Nijs J. Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: an experimental study. J Rehabil Med. 2010b;42(9):884-890.
Arendt-Nielsen L, Egsgaard LL, Petersen KK, et al. A mechanism-based pain sensitivity index to characterize knee osteoarthritis patients with different disease stages and pain levels. Eur J Pain. 2015;19(10):1406-1417.
Krüger S, Hilberg T. Neuropathic pain in patients with haemophilia, that is the question. Hamostaseologie. 2015;35:S5-S9.
Krüger S, Weitz C, Runkel B, Hilberg T. Pain sensitivity in patients with haemophilia following moderate aerobic exercise intervention. Haemophilia. 2016;22(6):886-893.
Finnerup NB, Haroutounian S, Kamerman P, et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016;157(8):1599-1606.
Raja SN, Carr DB, Cohen M, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161:1976-1982.
Oldenburg J. Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens. Blood. 2015;125(13):2038-2044.
Schwarzkopf SR, Ewert T, Dreinhöfer KE, Cieza A, Stucki G. Towards an ICF Core Set for chronic musculoskeletal conditions: commonalities across ICF Core Sets for osteoarthritis, rheumatoid arthritis, osteoporosis, low back pain and chronic widespread pain. Clin Rheumatol. 2008;27(11):1355-1361.
Baert IAC, Staes F, Truijen S, et al. Weak associations between structural changes on MRI and symptoms, function and muscle strength in relation to knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2014;22(9):2013-2025.
Lundin B, Manco-Johnson ML, Ignas DM, et al. An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group. Haemophilia. 2012;18(6):962-970.
Foppen W, Van Der Schaaf IC, Witkamp TD, Fischer K. Is joint effusion on MRI specific for haemophilia? Haemophilia. 2014;20(4):582-586.
Martinoli C, Alberighi OD, Di Minno G, et al. Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US). Thromb Haemost. 2013;109(6):1170-1179.
Hilliard P, Funk S, Zourikian N, et al. Hemophilia joint health score reliability study. Haemophilia. 2006;12(5):518-525.
Gouw SC, Timmer MA, Srivastava A, et al. Measurement of joint health in persons with haemophilia: A systematic review of the measurement properties of haemophilia-specific instruments. Haemophilia. 2019;25(1):e1-e10.
Podsiadlo D, Richardson S. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142-148.
Butland RJ, Pang J, Gross ER, Woodcock AA, Geddes DM. Two-, six-, and 12-minute walking tests in respiratory disease. Br Med J (Clin Res Ed). 1982;284(6329):1607-1608.
Yuksel E, Kalkan S, Cekmece S, Unver B, Karatosun V. Assessing minimal detectable changes and test-retest reliability of the timed up and go test and the 2-minute walk test in patients with total knee arthroplasty. J Arthroplasty. 2017;32(2):426-430.
Genderen FR, Meeteren NLU, Bom JG, et al. Functional consequences of haemophilia in adults: the development of the Haemophilia Activities List. Haemophilia. 2004;10(5):565-571.
Buckner TW, Sidonio R, Guelcher C, et al. Reliability and validity of patient-reported outcome instruments in US adults with hemophilia B and caregivers in the B-HERO-S study. Eur J Haematol. 2018;101(6):781-790.
Stanhope J. Brief pain inventory review. Occup Med. 2016;66(6):496-497.
Timmerman H, Steegers MAH, Huygen F, et al. Investigating the validity of the DN4 in a consecutive population of patients with chronic pain. PLoS One. 2017;12(11):e0187961.
Vargas-Schaffer G. Is the WHO analgesic ladder still valid? Twenty-four years of experience. Can Fam Physician. 2010;56(6):514-517.
Cao J, Zhang S. Multiple comparison procedures. JAMA. 2014;312(5):543-544.
Schober P, Boer C, Schwarte LA. Correlation coefficients: appropriate use and interpretation. Anesth Analg. 2018;126(5):1763-1768.
Hinkle DE, Wiersma W, Jurs SG. Applied Statistics for the Behavioral Sciences. Houghton Mifflin. 2002.
Brunel T, Lobet S, Deschamps K, et al. Reliability and clinical features associated with the IPSG MRI tibiotalar and subtalar joint scores in children, adolescents and young adults with haemophilia. Haemophilia. 2018;24(1):141-148.
Plut D, Faganel Kotnik B, Preložnik Zupan I, et al. Detection and evaluation of haemophilic arthropathy: which tools may be considered more reliable. Haemophilia. 2021;27(1):156-163.
Timmer MA, Foppen W, Schutgens REG, Pisters MF, Fischer K. Comparing findings of routine Haemophilia Joint Health Score and Haemophlia Early Arthropathy Detection with UltraSound assessments in adults with haemophilia. Haemophilia. 2017;23(2):e141-e143.
Kear BM, Guck TP, McGaha AL. Timed Up and Go (TUG) test: normative reference values for ages 20 to 59 years and relationships with physical and mental health risk factors. J Prim Care Community Health. 2017;8(1):9-13.
Baumgardner J, Elon L, Antun A, et al. Physical activity and functional abilities in adult males with haemophilia: a cross-sectional survey from a single US haemophilia treatment centre. Haemophilia. 2013;19(4):551-557.
Bohannon RW, Wang Y-C, Gershon RC. Two-minute walk test performance by adults 18 to 85 years: normative values, reliability, and responsiveness. Arch Phys Med Rehabil. 2015;96(3):472-477.
Mclaughlin P, Morris R, Chowdary P. Investigating the relationship between the HJHS and HAL in routine clinical practice: a retrospective review. Haemophilia. 2018;24(6):988-994.
McLaughlin P, Hurley M, Chowdary P, Stephensen D, Khair K. The experiences and beliefs of people with severe haemophilia and healthcare professionals on pain management, and their views of using exercise as an aspect of intervention: a qualitative study. Disabil Rehabil. 2021:1-9.
Krüger S, Hoffmeister M, Hilberg T. Pain and structural alterations in knee joints in patients with haemophilia. Haemophilia. 2018;24:657-666.
Kruger S, Herzig M, Hilberg T. Changes in pain profile of patients with haemophilia during 1-year follow-up. Haemophilia. 2021;27(5):783-792.
Thakur M, Dickenson AH, Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol. 2014;10(6):374-380.
Nicholas M, Vlaeyen JWS, Rief W, et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain. 2019;160(1):28-37.
Bailly F, Cantagrel A, Bertin P, et al. Part of pain labelled neuropathic in rheumatic disease might be rather nociplastic. RMD Open. 2020;6(2):e001326.