Echinocandins - structure, mechanism of action and use in antifungal therapy.
Anidulafungin
caspofungin
chemical modification
drug resistance
micafungin
rezafungin
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
17
3
2022
pubmed:
18
3
2022
medline:
22
3
2022
Statut:
ppublish
Résumé
With increasing number of immunocompromised patients as well as drug resistance in fungi, the risk of fatal fungal infections in humans increases as well. The action of echinocandins is based on the inhibition of β-(1,3)-d-glucan synthesis that builds the fungal cell wall. Caspofungin, micafungin, anidulafungin and rezafungin are semi-synthetic cyclic lipopeptides. Their specific chemical structure possess a potential to obtain novel derivatives with better pharmacological properties resulting in more effective treatment, especially in infections caused by
Identifiants
pubmed: 35296203
doi: 10.1080/14756366.2022.2050224
pmc: PMC8933026
doi:
Substances chimiques
Antifungal Agents
0
Echinocandins
0
Glucans
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
876-894Références
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