CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection.
Animals
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ genetics
Disease Models, Animal
Escherichia coli Infections
/ drug therapy
Escherichia coli Proteins
/ metabolism
Female
Gene Expression Regulation, Bacterial
Humans
Male
Mice
Phosphoric Monoester Hydrolases
/ genetics
Protein Kinases
/ genetics
Salmonella typhimurium
/ metabolism
Urinary Tract Infections
/ drug therapy
Uropathogenic Escherichia coli
Virulence Factors
/ genetics
CpxRA
Escherichia coli
UPEC
phosphatase inhibitor
treatment
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
27 04 2022
27 04 2022
Historique:
pubmed:
18
3
2022
medline:
30
4
2022
entrez:
17
3
2022
Statut:
ppublish
Résumé
CpxRA is an envelope stress response system that is highly conserved in the
Identifiants
pubmed: 35297652
doi: 10.1128/spectrum.02430-21
pmc: PMC9045377
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Escherichia coli Proteins
0
Virulence Factors
0
Protein Kinases
EC 2.7.-
CpxA protein, E coli
EC 2.7.3.-
Phosphoric Monoester Hydrolases
EC 3.1.3.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243021Subventions
Organisme : NIAID NIH HHS
ID : R01 AI027863
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136795
Pays : United States
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