Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
08
2021
accepted:
11
03
2022
entrez:
24
3
2022
pubmed:
25
3
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Salmonella enterica is the most common foodborne pathogen worldwide. It causes two types of diseases, a self-limiting gastroenteritis and an invasive, more threatening, infection. Salmonella gastroenteritis is caused by several serotypes and is common worldwide. In contrast, invasive salmonellosis is rare in high-income countries (HIC) while frequent in low- and middle-income countries (LMIC), especially in sub-Saharan Africa (sSA). Invasive Nontyphoidal Salmonella (iNTS), corresponding to serotypes other than Typhi and Paratyphi, have emerged in sSA and pose a significant risk to public health. We conducted a whole-genome sequence (WGS) analysis of 72 strains of Salmonella isolated from diarrheic human patients and chicken meat sold in multipurpose markets in Dakar, Senegal. Antimicrobial susceptibility testing combined with WGS data analysis revealed frequent resistance to fluoroquinolones and the sulfamethoxazole-trimethoprim combination that are among the most used treatments for invasive Salmonella. In contrast, resistance to the historical first-line drugs chloramphenicol and ampicillin, and to cephalosporins was rare. Antimicrobial resistance (AMR) was lower in clinical isolates compared to chicken strains pointing to the concern posed by the excessive use of antimicrobials in farming. Phylogenetic analysis suggested possible transmission of the emerging multidrug resistant (MDR) Kentucky ST198 and serotype Schwarzengrund from chicken to human. These results stress the need for active surveillance of Salmonella and AMR in order to address invasive salmonellosis caused by nontyphoidal Salmonella strains and other important bacterial diseases in sSA.
Identifiants
pubmed: 35325007
doi: 10.1371/journal.pone.0266025
pii: PONE-D-21-24873
pmc: PMC8947133
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0266025Subventions
Organisme : FDA HHS
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Appl Environ Microbiol. 2013 Sep;79(17):5167-78
pubmed: 23793629
Microorganisms. 2019 Nov 21;7(12):
pubmed: 31766493
Microbiol Spectr. 2016 Jun;4(3):
pubmed: 27337467
PLoS One. 2016 Jun 29;11(6):e0157683
pubmed: 27355480
Int J Food Microbiol. 2006 Jul 15;110(2):178-86
pubmed: 16774796
Clin Microbiol Infect. 2012 Mar;18(3):268-81
pubmed: 21793988
Nat Microbiol. 2021 Mar;6(3):327-338
pubmed: 33349664
Clin Infect Dis. 2020 Jul 29;71(Suppl 2):S102-S110
pubmed: 32725221
Lancet. 1950 Nov 25;2(6639):621-3
pubmed: 14785226
J Antimicrob Chemother. 2020 Dec 1;75(12):3491-3500
pubmed: 32780112
Clin Microbiol Infect. 2016 Feb;22(2):110-121
pubmed: 26708671
Br Poult Sci. 2005 Apr;46(2):204-10
pubmed: 15957441
BMJ Glob Health. 2021 Aug;6(8):
pubmed: 34341020
Lancet. 1991 Jun 8;337(8754):1422
pubmed: 1674805
Clin Microbiol Rev. 2015 Oct;28(4):901-37
pubmed: 26180063
J Clin Microbiol. 2012 Apr;50(4):1355-61
pubmed: 22238442
Rev Elev Med Vet Pays Trop. 1973;26(3):279-87
pubmed: 4801995
Clin Infect Dis. 2015 Nov 1;61 Suppl 4:S346-53
pubmed: 26449951
Bioinformatics. 2016 Nov 15;32(22):3380-3387
pubmed: 27466620
Infect Immun. 1999 Nov;67(11):5587-96
pubmed: 10531204
Risk Anal. 2012 Oct;32(10):1798-819
pubmed: 22489615
Int J Infect Dis. 2006 Nov;10(6):434-8
pubmed: 16978898
Vet World. 2019;12(4):504-521
pubmed: 31190705
Appl Environ Microbiol. 2019 Nov 14;85(23):
pubmed: 31540993
Clin Infect Dis. 2001 Jan 15;32(2):263-9
pubmed: 11170916
J Clin Microbiol. 2000 Jul;38(7):2465-7
pubmed: 10878026
EcoSal Plus. 2019 Jan;8(2):
pubmed: 30657108
Avian Pathol. 2017 Apr;46(2):119-124
pubmed: 27791403
Appl Environ Microbiol. 2019 Aug 1;85(16):
pubmed: 31175193
Clin Infect Dis. 2015 Nov 1;61 Suppl 4:S317-24
pubmed: 26449947
Prev Vet Med. 2004 May 14;63(3-4):151-61
pubmed: 15158567
MMWR Morb Mortal Wkly Rep. 2019 Jan 11;68(1):11-13
pubmed: 30629573
PLoS Negl Trop Dis. 2017 Jan 5;11(1):e0005118
pubmed: 28056035
Lancet Glob Health. 2017 Mar;5(3):e310-e323
pubmed: 28193398
Rev Elev Med Vet Pays Trop. 1971;24(1):9-18
pubmed: 5106015
J Glob Antimicrob Resist. 2013 Dec;1(4):231-232
pubmed: 27873620
J Med Microbiol. 1996 May;44(5):317-9
pubmed: 8636944
Rev Elev Med Vet Pays Trop. 1976;29(4):313-6
pubmed: 1019394
J Antimicrob Chemother. 2017 Oct 1;72(10):2764-2768
pubmed: 29091202
Public Health Rep. 2012 Jan-Feb;127(1):4-22
pubmed: 22298919
Malar J. 2014 Oct 13;13:400
pubmed: 25311375
J Microbiol. 2019 Jul;57(7):541-549
pubmed: 31016564
Antimicrob Agents Chemother. 2012 Oct;56(10):5096-102
pubmed: 22802251
Microb Genom. 2019 Jul;5(7):
pubmed: 31107206
Front Microbiol. 2016 Feb 25;7:203
pubmed: 26941727
Int J Food Microbiol. 2005 Aug 25;103(2):157-65
pubmed: 16083818
Rev Elev Med Vet Pays Trop. 1976;29(3):205-9
pubmed: 1005841
Trop Anim Health Prod. 2011 Jun;43(5):983-8
pubmed: 21327860
Clin Microbiol Infect. 2014 Feb;20(2):O109-16
pubmed: 23992040
J Mol Microbiol Biotechnol. 2004;7(4):155-69
pubmed: 15383714
Int J Food Microbiol. 2008 Apr 30;123(3):191-7
pubmed: 18325615
Microbiol Mol Biol Rev. 2020 Jul 29;84(3):
pubmed: 32727743
Foodborne Pathog Dis. 2019 Feb;16(2):130-136
pubmed: 30707626
J Clin Microbiol. 2001 Jun;39(6):2373-4
pubmed: 11414247
J Comput Biol. 2013 Oct;20(10):714-37
pubmed: 24093227
PLoS One. 2014 Aug 11;9(8):e104984
pubmed: 25110940