A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
14 04 2022
14 04 2022
Historique:
pubmed:
26
3
2022
medline:
16
4
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis, which is at least partly mediated through agonism of natriuretic peptide receptor C (NPR-C), and loss of this signaling has been associated with vascular dysfunction. As such, NPR-C is a novel therapeutic target to treat cardiovascular diseases. A series of novel small molecules have been designed and synthesized, and their structure-activity relationships were evaluated by a surface plasmon resonance binding assay. The biological activity of hit compounds was confirmed through organ bath assays measuring vascular relaxation and inhibition of cAMP production, which was shown to be linked to its NPR-C activity. Lead compound
Identifiants
pubmed: 35333039
doi: 10.1021/acs.jmedchem.1c01974
pmc: PMC9014859
doi:
Substances chimiques
Natriuretic Peptide, C-Type
127869-51-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5495-5513Subventions
Organisme : British Heart Foundation
ID : TG/15/3/31692
Pays : United Kingdom
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