Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.
asymmetry
cortical thickness
gradients
multi-site
temporal lobe epilepsy
Journal
Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537
Informations de publication
Date de publication:
24 05 2022
24 05 2022
Historique:
received:
10
05
2021
revised:
15
07
2021
accepted:
14
08
2021
pubmed:
26
3
2022
medline:
27
5
2022
entrez:
25
3
2022
Statut:
ppublish
Résumé
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy.
Identifiants
pubmed: 35333312
pii: 6432033
doi: 10.1093/brain/awab417
pmc: PMC9128824
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1285-1298Subventions
Organisme : NINDS NIH HHS
ID : R21 NS107739
Pays : United States
Organisme : Medical Research Council
ID : MR/S00355X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K013998/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS122827
Pays : United States
Organisme : Medical Research Council
ID : MR/N008324/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110347
Pays : United States
Informations de copyright
© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.
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