Characterization of hypervirulent Klebsiella pneumoniae isolates in Belgium.
Capsular serotype
Hypermucoviscosity
Hypervirulence
Klebsiella pneumoniae
Molecular epidemiology
Whole genome sequencing
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
30
12
2021
accepted:
23
03
2022
pubmed:
31
3
2022
medline:
27
4
2022
entrez:
30
3
2022
Statut:
ppublish
Résumé
Hypervirulent Klebsiella pneumoniae (hvKp) raised concern worldwide. We studied 22 hvKp clinical invasive isolates referred to the Belgian national reference laboratory between 2014 and 2020. Sixty-four percent of the isolates expressed K2 capsular serotype and belonged to 7 different MLST lineages, while 32% expressed K1 (all belonging to ST23) and were associated with liver abscesses. Primary extra-hepatic infections were reported in 36% and sepsis for 95% of the patients with 30% of deaths. Improved clinical and microbiological diagnostics are required as hvKp may represent an underestimated cause of community-acquired invasive infections in Belgium.
Identifiants
pubmed: 35353281
doi: 10.1007/s10096-022-04438-z
pii: 10.1007/s10096-022-04438-z
doi:
Substances chimiques
Virulence Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
859-865Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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