The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.
Adenosine Triphosphate
/ metabolism
Animals
Caspase 1
/ metabolism
Diabetes Mellitus, Type 2
Inflammasomes
/ metabolism
Interleukin-1beta
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
NLR Family, Pyrin Domain-Containing 3 Protein
/ genetics
Potassium
/ metabolism
Potassium Channels
Potassium Channels, Tandem Pore Domain
/ metabolism
NLRP3
THIK-1
inflammasome
inflammation
interleukin-1
potassium channel
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
15
03
2022
received:
07
01
2022
accepted:
21
03
2022
pubmed:
31
3
2022
medline:
10
5
2022
entrez:
30
3
2022
Statut:
ppublish
Résumé
The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi-protein complex responsible for the activation of caspase-1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL-1β and IL-18, and pyroptotic cell death. NLRP3 is implicated as a driver of inflammation in a range of disorders including neurodegenerative diseases, type 2 diabetes, and atherosclerosis. A commonly reported mechanism contributing to NLRP3 inflammasome activation is potassium ion (K
Identifiants
pubmed: 35353387
doi: 10.1002/glia.24174
pmc: PMC9314991
doi:
Substances chimiques
Inflammasomes
0
Interleukin-1beta
0
Kcnk13 protein, mouse
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Nlrp3 protein, mouse
0
Potassium Channels
0
Potassium Channels, Tandem Pore Domain
0
Adenosine Triphosphate
8L70Q75FXE
Caspase 1
EC 3.4.22.36
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1301-1316Subventions
Organisme : Medical Research Council
ID : MR/N013751/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T016515/1
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. GLIA published by Wiley Periodicals LLC.
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