David Brough

Affiliations

Division of Neuroscience & Experimental Psychology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Publications (26)

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA.

EMBO molecular medicine

Avec: Helen Parker , Stuart M Ellison , Rebecca J Holley , Claire O'Leary , Aiyin Liao , Jalal Asadi , Emily Glover , Arunabha Ghosh , Simon Jones , Fiona L Wilkinson , David Brough , Emmanuel Pinteaux , Hervé Boutin , Brian W Bigger

Microglial Priming as Trained Immunity in the Brain.

Neuroscience

Avec: Michael J Haley , David Brough , Jessica Quintin , Stuart M Allan

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.

Immunology

Avec: Sohaib Nizami , Kanisa Arunasalam , Jack Green , James Cook , Catherine B Lawrence , Tryfon Zarganes-Tzitzikas , John B Davis , Elena Di Daniel , David Brough

Brazilin is a natural product inhibitor of the NLRP3 inflammasome.

iScience

Avec: Emily McMahon , Sherihan El-Sayed , Jack Green , Christopher Hoyle , Lorna FitzPatrick , Emma V Jones , Eve Corrie , Rebecca L Kelly , Mairi Challinor , Sally Freeman , Richard A Bryce , Catherine B Lawrence , David Brough , Paul R Kasher

The Application of Knowledge Engineering via the use of a Biomimetic Digital Twin Ecosystem, Phenotype Driven Variant Analysis, and Exome Sequencing to Understand the Molecular Mechanisms of Disease.

The Journal of molecular diagnostics : JMD

Avec: William G Kearns , J Georgios Stamoulis , Joseph Glick , Lawrence Baisch , Andrew Benner , Dalton Brough , Luke Du , Bradford Wilson , Laura Kearns , Nicholas Ng , Maya Seshan , Raymond Anchan

Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome.

Bioorganic chemistry

Avec: Sherihan El-Sayed , Emily McMahon , Sondos Musleh , Sally Freeman , David Brough , Paul R Kasher , Richard A Bryce

Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Alistair L Chenery , Rafid Alhallaf , Zainab Agha , Jesuthas Ajendra , James E Parkinson , Martha M Cooper , Brian H K Chan , Ramon M Eichenberger , Lindsay A Dent , Avril A B Robertson , Andreas Kupz , David Brough , Alex Loukas , Tara E Sutherland , Judith E Allen , Paul R Giacomin

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

The Journal of biological chemistry

Avec: Victor S Tapia , Michael J D Daniels , Pablo Palazón-Riquelme , Matthew Dewhurst , Nadia M Luheshi , Jack Rivers-Auty , Jack Green , Elena Redondo-Castro , Philipp Kaldis , Gloria Lopez-Castejon , David Brough

A screening-level assessment of the pollinator-attractiveness of ornamental nursery stock using a honey bee foraging assay.

Scientific reports

Avec: Douglas B Sponsler , Christina M Grozinger , Rodney T Richardson , Andrea Nurse , Dalton Brough , Harland M Patch , Kimberly A Stoner

Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation.

Pharmaceuticals (Basel, Switzerland)

Avec: Xenia Kodji , Zizheng Kee , Robyn McKenna , Joao de Sousa Valente , Harriet Ravenscroft , Hayley McMillan , John Gamble , Yvonne Dombrowski , Paul Moynagh , David Brough , Fionnuala T Lundy , Susan D Brain , Ikhlas A El Karim

LRRC8A is dispensable for a variety of microglial functions and response to acute stroke.

Glia

Avec: James R Cook , Anna L Gray , Eloise Lemarchand , Ingo Schiessl , Jack P Green , Mary C Newland , Douglas P Dyer , David Brough , Catherine B Lawrence

The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation.

Glia

Avec: Samuel Drinkall , Catherine B Lawrence , Bernadino Ossola , Samuel Russell , Clare Bender , Nicola B Brice , Lee A Dawson , Michael Harte , David Brough

Lymphatic network drainage resolves cerebral edema and facilitates recovery from experimental cerebral malaria.

Cell reports

Avec: Michael J Haley , Ruben Barroso , Dhifaf A Jasim , Megan Haigh , Jack Green , Ben Dickie , Alister G Craig , David Brough , Kevin N Couper

Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.

Science advances

Avec: Michael J Haley , Leoma Bere , James Minshull , Sokratia Georgaka , Natalia Garcia-Martin , Gareth Howell , David J Coope , Federico Roncaroli , Andrew King , David C Wedge , Stuart M Allan , Omar N Pathmanaban , David Brough , Kevin N Couper

Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions.

Nature communications

Avec: Rose Wellens , Victor S Tapia , Paula I Seoane , Hayley Bennett , Antony Adamson , Graham Coutts , Jack Rivers-Auty , Martin Lowe , Jack P Green , Gloria Lopez-Castejon , David Brough , Christopher Hoyle

The comparable tumour microenvironment in sporadic and

Brain communications

Avec: Grace E Gregory , Adam Paul Jones , Michael J Haley , Christopher Hoyle , Leo A H Zeef , I-Hsuan Lin , David J Coope , Andrew T King , D Gareth Evans , Pawel Paszek , Kevin N Couper , David Brough , Omar N Pathmanaban

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.

iScience

Avec: Jack P Green , Lina Y El-Sharkawy , Stefan Roth , Jie Zhu , Jiayu Cao , Andrew G Leach , Arthur Liesz , Sally Freeman , David Brough

Trends in Subcutaneous Tumour Height and Impact on Measurement Accuracy.

Cancer informatics

Avec: Daniel Brough , Hope Amos , Karl Turley , Jake Murkin

Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium.

Cell death discovery

Avec: Paula I Seoane , James A Beswick , Andrew G Leach , Tessa Swanton , Lucy V Morris , Kevin Couper , Martin Lowe , Sally Freeman , David Brough

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture.

Immunology

Avec: Christopher Hoyle , Elena Redondo-Castro , James Cook , Te-Chen Tzeng , Stuart M Allan , David Brough , Eloise Lemarchand

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease.

Journal of visualized experiments : JoVE

Avec: Bushra Almari , David Brough , Michael Harte , Annalisa Tirella

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Stroke

Avec: Eloise Lemarchand , Jack Barrington , Alistair Chenery , Michael Haley , Graham Coutts , Judith E Allen , Stuart M Allan , David Brough

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

PLoS pathogens

Avec: Brian J McHugh , Rongling Wang , Hsin-Ni Li , Paula E Beaumont , Rebekah Kells , Holly Stevens , Lisa Young , Adriano G Rossi , Robert D Gray , Julia R Dorin , Emily L Gwyer Findlay , David Brough , Donald J Davidson

Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?

Brain communications

Avec: Jack Rivers-Auty , Alison E Mather , Ruth Peters , Catherine B Lawrence , David Brough

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification.

The FEBS journal

Avec: Shi Yu , Jack Green , Rose Wellens , Gloria Lopez-Castejon , David Brough

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes

Frontiers in immunology

Avec: Anna Gritsenko , Shi Yu , Fatima Martin-Sanchez , Ines Diaz-Del-Olmo , Eva-Maria Nichols , Daniel M Davis , David Brough , Gloria Lopez-Castejon

Réseau de co-auteurs

Jack Green 5 collaborations

Catherine B Lawrence 5 collaborations

Michael J Haley 4 collaborations

Stuart M Allan 4 collaborations

Christopher Hoyle 4 collaborations

Sally Freeman 4 collaborations

Gloria Lopez-Castejon 4 collaborations

Jack Rivers-Auty 3 collaborations

Eloise Lemarchand 3 collaborations

Jack P Green 3 collaborations

Kevin N Couper 3 collaborations

James Cook 2 collaborations

Emily McMahon 2 collaborations

Sherihan El-Sayed 2 collaborations

Richard A Bryce 2 collaborations

Paul R Kasher 2 collaborations

Dalton Brough 2 collaborations

Judith E Allen 2 collaborations

Victor S Tapia 2 collaborations

Elena Redondo-Castro 2 collaborations

Michael Harte 2 collaborations

David J Coope 2 collaborations

Omar N Pathmanaban 2 collaborations

Rose Wellens 2 collaborations

Paula I Seoane 2 collaborations

Graham Coutts 2 collaborations

Martin Lowe 2 collaborations

Andrew G Leach 2 collaborations

Shi Yu 2 collaborations

Helen Parker 1 collaboration

Stuart M Ellison 1 collaboration

Rebecca J Holley 1 collaboration

Claire O'Leary 1 collaboration

Aiyin Liao 1 collaboration

Jalal Asadi 1 collaboration

Emily Glover 1 collaboration

Arunabha Ghosh 1 collaboration

Simon Jones 1 collaboration

Fiona L Wilkinson 1 collaboration

Emmanuel Pinteaux 1 collaboration

Hervé Boutin 1 collaboration

Brian W Bigger 1 collaboration

Jessica Quintin 1 collaboration

Sohaib Nizami 1 collaboration

Kanisa Arunasalam 1 collaboration

Tryfon Zarganes-Tzitzikas 1 collaboration

John B Davis 1 collaboration

Elena Di Daniel 1 collaboration

Lorna FitzPatrick 1 collaboration

Emma V Jones 1 collaboration

Eve Corrie 1 collaboration

Rebecca L Kelly 1 collaboration

Mairi Challinor 1 collaboration

William G Kearns 1 collaboration

J Georgios Stamoulis 1 collaboration

Joseph Glick 1 collaboration

Lawrence Baisch 1 collaboration

Andrew Benner 1 collaboration

Luke Du 1 collaboration

Bradford Wilson 1 collaboration

Laura Kearns 1 collaboration

Nicholas Ng 1 collaboration

Maya Seshan 1 collaboration

Raymond Anchan 1 collaboration

Sondos Musleh 1 collaboration

Alistair L Chenery 1 collaboration

Rafid Alhallaf 1 collaboration

Zainab Agha 1 collaboration

Jesuthas Ajendra 1 collaboration

James E Parkinson 1 collaboration

Martha M Cooper 1 collaboration

Brian H K Chan 1 collaboration

Ramon M Eichenberger 1 collaboration

Lindsay A Dent 1 collaboration

Avril A B Robertson 1 collaboration

Andreas Kupz 1 collaboration

Alex Loukas 1 collaboration

Tara E Sutherland 1 collaboration

Paul R Giacomin 1 collaboration

Michael J D Daniels 1 collaboration

Pablo Palazón-Riquelme 1 collaboration

Matthew Dewhurst 1 collaboration

Nadia M Luheshi 1 collaboration

Philipp Kaldis 1 collaboration

Douglas B Sponsler 1 collaboration

Christina M Grozinger 1 collaboration

Rodney T Richardson 1 collaboration

Andrea Nurse 1 collaboration

Harland M Patch 1 collaboration

Kimberly A Stoner 1 collaboration

Xenia Kodji 1 collaboration

Zizheng Kee 1 collaboration

Robyn McKenna 1 collaboration

Joao de Sousa Valente 1 collaboration

Harriet Ravenscroft 1 collaboration

Hayley McMillan 1 collaboration

John Gamble 1 collaboration

Yvonne Dombrowski 1 collaboration

Paul Moynagh 1 collaboration

Fionnuala T Lundy 1 collaboration

Susan D Brain 1 collaboration

Ikhlas A El Karim 1 collaboration

James R Cook 1 collaboration

Anna L Gray 1 collaboration

Ingo Schiessl 1 collaboration

Mary C Newland 1 collaboration

Douglas P Dyer 1 collaboration

Samuel Drinkall 1 collaboration

Bernadino Ossola 1 collaboration

Samuel Russell 1 collaboration

Clare Bender 1 collaboration

Nicola B Brice 1 collaboration

Lee A Dawson 1 collaboration

Ruben Barroso 1 collaboration

Dhifaf A Jasim 1 collaboration

Megan Haigh 1 collaboration

Ben Dickie 1 collaboration

Alister G Craig 1 collaboration

Leoma Bere 1 collaboration

James Minshull 1 collaboration

Sokratia Georgaka 1 collaboration

Natalia Garcia-Martin 1 collaboration

Gareth Howell 1 collaboration

Federico Roncaroli 1 collaboration

Andrew King 1 collaboration

David C Wedge 1 collaboration

Hayley Bennett 1 collaboration

Antony Adamson 1 collaboration

Grace E Gregory 1 collaboration

Adam Paul Jones 1 collaboration

Leo A H Zeef 1 collaboration

I-Hsuan Lin 1 collaboration

Andrew T King 1 collaboration

D Gareth Evans 1 collaboration

Pawel Paszek 1 collaboration

Lina Y El-Sharkawy 1 collaboration

Stefan Roth 1 collaboration

Jie Zhu 1 collaboration

Jiayu Cao 1 collaboration

Arthur Liesz 1 collaboration

Daniel Brough 1 collaboration

Hope Amos 1 collaboration

Karl Turley 1 collaboration

Jake Murkin 1 collaboration

James A Beswick 1 collaboration

Tessa Swanton 1 collaboration

Lucy V Morris 1 collaboration

Kevin Couper 1 collaboration

Te-Chen Tzeng 1 collaboration

Bushra Almari 1 collaboration

Annalisa Tirella 1 collaboration

Jack Barrington 1 collaboration

Alistair Chenery 1 collaboration

Michael Haley 1 collaboration

Brian J McHugh 1 collaboration

Rongling Wang 1 collaboration

Hsin-Ni Li 1 collaboration

Paula E Beaumont 1 collaboration

Rebekah Kells 1 collaboration

Holly Stevens 1 collaboration

Lisa Young 1 collaboration

Adriano G Rossi 1 collaboration

Robert D Gray 1 collaboration

Julia R Dorin 1 collaboration

Emily L Gwyer Findlay 1 collaboration

Donald J Davidson 1 collaboration

Alison E Mather 1 collaboration

Ruth Peters 1 collaboration

Anna Gritsenko 1 collaboration

Fatima Martin-Sanchez 1 collaboration

Ines Diaz-Del-Olmo 1 collaboration

Eva-Maria Nichols 1 collaboration

Daniel M Davis 1 collaboration