Glutathione-Depleting Organic Metal Adjuvants for Effective NIR-II Photothermal Immunotherapy.
cancer treatment
glutathione depletion
organic metal adjuvants
photoacoustic imaging
photothermal immunotherapy
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
24
03
2022
received:
22
02
2022
pubmed:
1
4
2022
medline:
28
5
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic and photothermal properties as well as the ability to perturb redox homeostasis to potentiate immunogenicity and immune responsiveness. OMAs, assembled from charge-transfer complexes and characterized by a broad substrate scope, high accessibility, and flexibly tuned optical properties, demonstrate strong phototherapeutic and adjuvant abilities via the depletion of glutathione and cysteine, and subsequently elicit systemic immunity by evoking immunogenic cell death, promoting dendritic cell maturation, and increasing T cell infiltration. Furthermore, programmed cell death protein 1 antibody can be employed to synergize with OMAs to suppress tumor immune evasion and ultimately improve the treatment outcomes. This study unlocks new paradigms to provide a versatile OMA-based scaffold for future practical applications.
Identifiants
pubmed: 35357041
doi: 10.1002/adma.202201706
doi:
Substances chimiques
Adjuvants, Immunologic
0
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2201706Subventions
Organisme : National Natural Science Foundation of China
ID : 21972047
Organisme : Guangdong Provincial Pearl River Talents Program
ID : 2019QN01Y314
Organisme : Program for Guangdong Introducing Innovative and Entrepreneurial Teams
ID : 2019ZT08Y318
Organisme : Natural Science Foundation of Guangdong Province
ID : 2021A1515010724
Organisme : China Postdoctoral Science Foundation
ID : 2021M691063
Organisme : Fundamental Research Funds for the Central Universities of China
Organisme : Agency for Science, Technology and Research
ID : A20E5c0081
Organisme : Singapore National Research Foundation
ID : NRF-NRFI2018-03
Informations de copyright
© 2022 Wiley-VCH GmbH.
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