Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor.

Amino Acid Sequence Conotoxins / pharmacology Cysteine Disulfides Muscles / metabolism Nicotinic Antagonists / pharmacology Receptors, Nicotinic / metabolism
biological activity conotoxin nicotinic acetylcholine receptor peptide structure

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
20 04 2022
Historique:
pubmed: 1 4 2022
medline: 22 4 2022
entrez: 31 3 2022
Statut: ppublish

Résumé

α-Conotoxins that target muscle nicotinic acetylcholine receptors (nAChRs) commonly fall into two structural classes, frameworks I and II containing two and three disulfide bonds, respectively. Conotoxin SII is the sole member of the cysteine-rich framework II with ill-defined interactions at the nAChRs. Following directed synthesis of α-SII, NMR analysis revealed a well-defined structure containing a 3

Identifiants

DOI: 10.1021/acschemneuro.1c00857 PMID: 35357806
pubmed: 35357806
doi: 10.1021/acschemneuro.1c00857
doi:

Substances chimiques

Conotoxins 0
Disulfides 0
Nicotinic Antagonists 0
Receptors, Nicotinic 0
alpha-conotoxin SII 143294-31-9
Cysteine K848JZ4886

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1245-1250

Auteurs

Patrick Wilhelm (P)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
ORCID: 0000-0002-5164-248X

Karen Luna-Ramirez (K)

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW 2522, Australia.

Yanni K-Y Chin (YK)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD 4072, Australia.

Zoltan Dekan (Z)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

Nikita Abraham (N)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

Han-Shen Tae (HS)

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW 2522, Australia.
ORCID: 0000-0001-8961-7194

Chun Yuen Chow (CY)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
ORCID: 0000-0003-2861-5843

David A Eagles (DA)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

Glenn F King (GF)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

Richard J Lewis (RJ)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.

David J Adams (DJ)

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW 2522, Australia.
ORCID: 0000-0002-7030-2288

Paul F Alewood (PF)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
ORCID: 0000-0001-7454-6522

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Cysteine-Rich α-Conotoxin SII Displays Novel...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Cysteine-Rich α-Conotoxin SII Displays Novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Cysteine-Rich α-Conotoxin SII Displays Novel...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Disulfures › Cysteine-Rich α-Conotoxin SII Displays Novel...
questionsmedicales.fr › Tissus › Muscles › Cysteine-Rich α-Conotoxin SII Displays Novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Antagonistes cholinergiques › Antagonistes nicotiniques › Cysteine-Rich α-Conotoxin SII Displays Novel...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Cysteine-Rich α-Conotoxin SII Displays Novel...