Fibroblast growth factor 19 stimulates water intake.
Endocrine
FGFR4
Hepatocellular carcinoma
Hydrodynamic gene transfer
Liver
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
17
12
2021
revised:
18
03
2022
accepted:
27
03
2022
pubmed:
4
4
2022
medline:
11
5
2022
entrez:
3
4
2022
Statut:
ppublish
Résumé
Fibroblast growth factor 19 (FGF19) is a hormone with pleiotropic metabolic functions, leading to ongoing development of analogues for treatment of metabolic disorders. On the other hand, FGF19 is overexpressed in a sub-group of hepatocellular carcinoma (HCC) patients and has oncogenic properties. It is therefore crucial to precisely define FGF19 effects, notably in the context of chronic exposure to elevated concentrations of the hormone. Here, we used hydrodynamic gene transfer to generate a transgenic mouse model with long-term FGF19 hepatic overexpression. We describe a novel effect of FGF19, namely the stimulation of water intake. This phenotype, lasting at least over a 6-month period, depends on signaling in the central nervous system and is independent of FGF21, although it mimics some of its features. We further show that HCC patients with high levels of circulating FGF19 have a reduced natremia, indicating dipsogenic features. The present study provides evidence of a new activity of FGF19, which could be clinically relevant in the context of FGF19 overexpressing cancers and in the course of treatment of metabolic disorders by FGF19 analogues.
Identifiants
pubmed: 35367668
pii: S2212-8778(22)00052-7
doi: 10.1016/j.molmet.2022.101483
pmc: PMC9019402
pii:
doi:
Substances chimiques
Hormones
0
fibroblast growth factor 15, mouse
0
Fibroblast Growth Factors
62031-54-3
Receptor, Fibroblast Growth Factor, Type 4
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101483Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier GmbH.. All rights reserved.
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