Knockout of P-glycoprotein abolish the collateral sensitivity of CHO
ABCB1
CRISPR-Knockout
Collateral sensitivity
Sorcin
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
11 06 2022
11 06 2022
Historique:
received:
17
03
2022
accepted:
27
03
2022
pubmed:
6
4
2022
medline:
29
4
2022
entrez:
5
4
2022
Statut:
ppublish
Résumé
Multidrug resistant tumor cells show collaterally sensitive to a range of non-toxic drugs. In this report, we describe the isolation of several P-glycoprotein-knockout cell clones, using CRISPR/Cas9, from Chinese hamster multidrug resistant model cell line and its parental cells (e.g., CHO
Identifiants
pubmed: 35381425
pii: S0006-291X(22)00493-4
doi: 10.1016/j.bbrc.2022.03.148
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Doxorubicin
80168379AG
Verapamil
CJ0O37KU29
Colchicine
SML2Y3J35T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-29Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest There are no conflicts of interest to report from either of the authors.