Understanding the Role of LFA-1 in Leukocyte Adhesion Deficiency Type I (LAD I): Moving towards Inflammation?
hematopoietic stem cell transplantation
inborn errors of immunity
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Mar 2022
25 Mar 2022
Historique:
received:
14
02
2022
revised:
18
03
2022
accepted:
21
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
LFA-1 (Lymphocyte function-associated antigen-1) is a heterodimeric integrin (CD11a/CD18) present on the surface of all leukocytes; it is essential for leukocyte recruitment to the site of tissue inflammation, but also for other immunological processes such as T cell activation and formation of the immunological synapse. Absent or dysfunctional expression of LFA-1, caused by mutations in the
Identifiants
pubmed: 35408940
pii: ijms23073578
doi: 10.3390/ijms23073578
pmc: PMC8998723
pii:
doi:
Substances chimiques
Lymphocyte Function-Associated Antigen-1
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : JF received funding from the LOEWE-Center Translational Medicine and Pharmacology in cooperation with the Fraunhofer Institute Frankfurt and the Patenschaftsmodell of the Goethe University Frankfurt. SB received funding from the Clinical Scientist Program
ID : xxxx
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