Epitope characterization of a monoclonal antibody that selectively recognizes KIR2DL1 allotypes.
killer immunoglobulin-like receptors
monoclonal antibodies
natural killer cells
polymorphism
site-directed mutagenesis
Journal
HLA
ISSN: 2059-2310
Titre abrégé: HLA
Pays: England
ID NLM: 101675570
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
06
04
2022
received:
12
01
2022
accepted:
08
04
2022
pubmed:
13
4
2022
medline:
20
7
2022
entrez:
12
4
2022
Statut:
ppublish
Résumé
Killer immunoglobulin-like receptor (KIR) genes code for a family of inhibitory and activating receptors, finely tuning NK cell function. Numerous studies reported the relevance of KIR allelic polymorphism on KIR expression, ligand affinity, and strength in signal transduction. Although KIR variability, including gene copy number and allelic polymorphism, in combination with HLA class I polymorphism, impacts both KIR expression and NK cell education, only a precise phenotypic analysis can define the size of the different KIR
Identifiants
pubmed: 35411634
doi: 10.1111/tan.14630
pmc: PMC9544867
doi:
Substances chimiques
Antibodies, Monoclonal
0
Epitopes
0
HLA-C Antigens
0
KIR2DL1 protein, human
0
Receptors, KIR
0
Receptors, KIR2DL1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-118Informations de copyright
© 2022 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons Ltd.
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