The relationship between sexual dimorphism and androgen response element proliferation in primate genomes.
Androgen
evolution
genome
hormone response elements
primates
sexual selection
Journal
Evolution; international journal of organic evolution
ISSN: 1558-5646
Titre abrégé: Evolution
Pays: United States
ID NLM: 0373224
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
04
03
2022
received:
24
03
2021
accepted:
13
03
2022
pubmed:
15
4
2022
medline:
25
6
2022
entrez:
14
4
2022
Statut:
ppublish
Résumé
In the males of many vertebrate species, sexual selection has led to the evolution of sexually dimorphic traits, which often are developmentally controlled by androgen signaling involving androgen response elements (AREs). Evolutionary changes in the number and genomic locations of AREs can modify patterns of receptor regulation and potentially alter gene expression. Here, we use recently sequenced primate genomes to evaluate the hypothesis that the strength of sexual selection is related to the genome-wide number of AREs in a diversifying lineage. In humans, we find a higher incidence of AREs near male-biased genes and androgen-responsive genes when compared to randomly selected genes from the genome. In a set of primates, we find that gains or losses of AREs proximal to genes are correlated with changes in male expression levels and the degree of sex-biased expression of those genes. In a larger set of primates, we find that increases in indicators of sexual selection are correlated with genome-wide ARE counts. Our results suggest that the responsiveness of the genome to androgens in humans and their close relatives has been shaped by sexual selection that arises from competition among males for mating access to females.
Identifiants
pubmed: 35420699
doi: 10.1111/evo.14483
pmc: PMC9321733
doi:
Substances chimiques
Androgens
0
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
1331-1346Commentaires et corrections
Type : CommentIn
Type : ExpressionOfConcernIn
Type : RetractionIn
Informations de copyright
© 2022 The Authors. Evolution published by Wiley Periodicals LLC on behalf of The Society for the Study of Evolution.
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