Association study between HLA-A, -B, -C, -DRB1 alleles and Psoriatic arthritis in southern France.
Genetic Background
HLA
HLA-B*27
HLA-C*06
Psoriatic Arthritis
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
19
05
2021
revised:
24
03
2022
accepted:
05
04
2022
pubmed:
17
4
2022
medline:
18
5
2022
entrez:
16
4
2022
Statut:
ppublish
Résumé
Psoriatic arthritis (PsA) is a type of inflammatory arthritis associated with psoriasis. HLA association studies performed in northern Europe, comparing patients with control populations, have shown that the highest risk for PsA is carried by HLA-C*06, HLA-B*57 and HLA-B*27 alleles. This retrospective association study compared HLA-A, -B, -C, and -DR alleles of 500 patients from southern France, who fulfilled the CASPAR criteria for Psoriatic Arthritis (PsA), with 2346 controls from healthy blood donors, using the chi-square test. We classified PsA patients into three different subgroups according to disease: purely axial, purely peripheral and combined axial and peripheral. The 'axial' subgroup was associated with HLA-B*27 (OR = 16.3, p = 2.7 × 10
Identifiants
pubmed: 35428536
pii: S0198-8859(22)00071-4
doi: 10.1016/j.humimm.2022.04.001
pii:
doi:
Substances chimiques
HLA-A Antigens
0
HLA-B Antigens
0
HLA-C Antigens
0
HLA-DRB1 Chains
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-520Informations de copyright
Copyright © 2022 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.