Biomonitoring of ochratoxin A, 2'R-ochratoxin A and citrinin in human blood serum from Switzerland.
2′R-Ochratoxin A
Citrinin
Dihydrocitrinone
Human serum
Ochratoxin A
Ochratoxin alpha
Journal
Mycotoxin research
ISSN: 1867-1632
Titre abrégé: Mycotoxin Res
Pays: Germany
ID NLM: 8807334
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
22
12
2021
accepted:
25
03
2022
revised:
24
03
2022
pubmed:
22
4
2022
medline:
28
4
2022
entrez:
21
4
2022
Statut:
ppublish
Résumé
Biomonitoring of mycotoxins and their metabolites in biological fluids is increasingly used to assess human exposure. In this study, biomarkers of ochratoxin A (OTA) and citrinin (CIT) exposure were determined in a large number of serum samples from healthy blood donors in Switzerland. In 2019, 700 samples from different regions were obtained. From 240 donors, a second sample (taken 2-9 months later) was available for analysis. Moreover, 355 blood donor samples from 2005 from all regions in Switzerland and 151 additional samples from the southern Swiss region of Ticino from 2005 could be analysed.OTA, 2'R-ochratoxin A (2'R-OTA), ochratoxin alpha (OTα), CIT and dihydrocitrinone (DH-CIT) were analysed using validated targeted methods including precipitation and online SPE clean-up.OTA and 2'R-OTA were frequently detected (OTA in 99%; 2'R-OTA in 51% of the tested samples). The mean concentration in all positive samples was 0.4 ng/mL for OTA and 0.2 ng/mL for 2'R-OTA. OTα was not detected in any sample above the limit of quantification (LOQ). In contrast to OTA, CIT and DH-CIT were only quantifiable in 2% and 0.1% of the samples, respectively. No significant trend was observed between the samples from 2005 and the more recent samples, but OTA concentrations were usually higher in serum samples from the southern Swiss region of Ticino and in males compared to females.Our extensive data fit well within the framework of previously published values for the healthy adult European population.
Identifiants
pubmed: 35446004
doi: 10.1007/s12550-022-00456-0
pii: 10.1007/s12550-022-00456-0
pmc: PMC9038883
doi:
Substances chimiques
Ochratoxins
0
ochratoxin A
1779SX6LUY
Citrinin
3S697X6SNZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-161Informations de copyright
© 2022. The Author(s).
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