Arabidopsis synaptotagmin 1 mediates lipid transport in a lipid composition-dependent manner.
SMP
endoplasmic reticulum
lipid transfer
membrane contact sites
plasma membrane
synaptotagmin
Journal
Traffic (Copenhagen, Denmark)
ISSN: 1600-0854
Titre abrégé: Traffic
Pays: England
ID NLM: 100939340
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
11
04
2022
received:
25
11
2021
accepted:
15
04
2022
pubmed:
23
4
2022
medline:
26
5
2022
entrez:
22
4
2022
Statut:
ppublish
Résumé
The endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCSs) are structurally conserved in eukaryotes. The Arabidopsis ER-anchored synaptotagmin 1 (SYT1), enriched in EPCSs, plays a critical role in plant abiotic stress tolerance. It has become clear that SYT1 interacts with PM to mediate ER-PM connectivity. However, whether SYT1 performs additional functions at EPCSs remains unknown. Here, we report that SYT1 efficiently transfers phospholipids between membranes. The lipid transfer activity of SYT1 is highly dependent on phosphatidylinositol 4,5-bisphosphate [PI(4,5)P
Substances chimiques
Arabidopsis Proteins
0
Phosphatidylinositols
0
SYT1 protein, Arabidopsis
0
Synaptotagmin I
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
346-356Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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