From Dietary Cholesterol to Blood Cholesterol, Physiological Lipid Fluxes, and Cholesterol Homeostasis.
absorption
bile
bile acids
cholesterol
extrahepatic
hepatic
intestine
lipoproteins
plant sterols
synthesis
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Apr 2022
14 Apr 2022
Historique:
received:
14
03
2022
revised:
04
04
2022
accepted:
12
04
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
27
4
2022
Statut:
epublish
Résumé
Dietary cholesterol (C) is a major contributor to the endogenous C pool, and it affects the serum concentration of total C, particularly the low-density lipoprotein cholesterol (LDL-C). A high serum concentration of LDL-C is associated with an increased risk for atherosclerosis and cardiovascular diseases. This concentration is dependent on hepatic C metabolism creating a balance between C input (absorption and synthesis) and C elimination (conversion to bile acids and fecal excretion). The daily C absorption rate is determined by dietary C intake, biliary C secretion, direct trans-intestinal C excretion (TICE), and the fractional C absorption rate. Hepatic C metabolism coordinates C fluxes entering the liver via chylomicron remnants (CMR), LDL, high-density lipoproteins (HDL), hepatic C synthesis, and those leaving the liver via very low-density lipoproteins (VLDL), biliary secretion, and bile acid synthesis. The knowns and the unknowns of this C homeostasis are discussed.
Identifiants
pubmed: 35458205
pii: nu14081643
doi: 10.3390/nu14081643
pmc: PMC9025004
pii:
doi:
Substances chimiques
Bile Acids and Salts
0
Cholesterol, Dietary
0
Cholesterol, LDL
0
Lipoproteins
0
Lipoproteins, VLDL
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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