Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes.

Granzymes / metabolism Humans Interferon-gamma / metabolism Multiple Sclerosis / metabolism Oligodendroglia RNA, Messenger / metabolism Th17 Cells / metabolism
CD4 T lymphocytes Th17 cells granzyme B human oligodendrocytes multiple sclerosis neuroinflammation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 07 01 2022
accepted: 07 03 2022
entrez: 28 4 2022
pubmed: 29 4 2022
medline: 30 4 2022
Statut: epublish

Résumé

Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4

Identifiants

DOI: 10.3389/fimmu.2022.850616 PMID: 35479072 PMC: PMC9035748
pubmed: 35479072
doi: 10.3389/fimmu.2022.850616
pmc: PMC9035748
doi:

Substances chimiques

RNA, Messenger 0
Interferon-gamma 82115-62-6
Granzymes EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

850616

Subventions

Organisme : CIHR
ID : 162430
Pays : Canada

Informations de copyright

Copyright © 2022 Jamann, Cui, Desu, Pernin, Tastet, Halaweh, Farzam-kia, Mamane, Ouédraogo, Cleret-Buhot, Daigneault, Balthazard, Klement, Lemaître, Arbour, Antel, Stratton and Larochelle.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Hélène Jamann (H)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Qiao-Ling Cui (QL)

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Haritha L Desu (HL)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Florian Pernin (F)

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Olivier Tastet (O)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.

Alexandre Halaweh (A)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Microbiology, Immunology and Infectiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Negar Farzam-Kia (N)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Victoria Hannah Mamane (VH)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Oumarou Ouédraogo (O)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Microbiology, Immunology and Infectiology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Aurélie Cleret-Buhot (A)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.

Audrey Daigneault (A)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.

Renaud Balthazard (R)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Wendy Klement (W)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Florent Lemaître (F)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Nathalie Arbour (N)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

Jack Antel (J)

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Jo Anne Stratton (JA)

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Catherine Larochelle (C)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montreal, QC, Canada.
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › Contact-Dependent Granzyme B-Mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Contact-Dependent Granzyme B-Mediated...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Contact-Dependent Granzyme B-Mediated...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Contact-Dependent Granzyme B-Mediated...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Contact-Dependent Granzyme B-Mediated...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Contact-Dependent Granzyme B-Mediated...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Contact-Dependent Granzyme B-Mediated...