Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges.
Clinical medicine
Mitochondrial transfer
Mitochondrial transplantation
Mitochondrial transplantation in medicine
Journal
Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
04
01
2022
revised:
24
03
2022
accepted:
27
04
2022
pubmed:
4
5
2022
medline:
27
7
2022
entrez:
3
5
2022
Statut:
ppublish
Résumé
Mitochondria, known as the powerhouse of the cell, are at the center of healthy physiology and provide cells with energy in the form of ATP. These unique organelles are also implicated in many pathological conditions affecting a variety of organs in various systems. Recently, mitochondrial transplantation, inspired by mitochondria's endosymbiotic origin, has been attempted as a potential biotherapy in mitigating a variety of pathological conditions. Mitochondrial transplantation consists of the process of isolation, transfer, and uptake of exogenous, intact mitochondria into damaged cells. Here, we discuss mitochondrial transplantation in the context of clinical medicine practiced in neurology, cardiology, pulmonary medicine, and oncology, among others. We outline the role of mitochondria in various pathologies and discuss the state-of-the-art research that potentially form the basis of new therapeutics for the treatment of a variety of diseases due to mitochondrial dysfunction. Lastly, we explore some of the challenges associated with mitochondrial transplantation that must be addressed before mitochondrial transplantation becomes a viable therapeutic option in clinical settings.
Identifiants
pubmed: 35504560
pii: S1567-7249(22)00040-X
doi: 10.1016/j.mito.2022.04.006
pmc: PMC9677933
mid: NIHMS1848087
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-44Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL153724
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD105889
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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