GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Animals
Antimicrobial Cationic Peptides
/ metabolism
Corticotropin-Releasing Hormone
/ metabolism
Eating
Food Deprivation
Ghrelin
/ metabolism
Hypothalamo-Hypophyseal System
/ metabolism
Male
Mice
Neurons
/ metabolism
Paraventricular Hypothalamic Nucleus
/ cytology
Pituitary-Adrenal System
/ metabolism
Receptors, Ghrelin
/ genetics
CRH neurons
Constitutive GHSR activity
Ghrelin
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
04 May 2022
04 May 2022
Historique:
received:
11
03
2022
accepted:
10
04
2022
revised:
08
04
2022
entrez:
3
5
2022
pubmed:
4
5
2022
medline:
6
5
2022
Statut:
epublish
Résumé
Prolonged fasting is a major challenge for living organisms. An appropriate metabolic response to food deprivation requires the activation of the corticotropin-releasing factor-producing neurons of the hypothalamic paraventricular nucleus (PVH We estimated the activation of the PVH We found that food deprivation results in the activation of the PVH Food deprivation-induced activation of the PVH
Identifiants
pubmed: 35504998
doi: 10.1007/s00018-022-04302-5
pii: 10.1007/s00018-022-04302-5
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Ghrelin
0
Ghsr1a protein, mouse
0
Leap2 protein, mouse
0
Receptors, Ghrelin
0
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
277Subventions
Organisme : Fondo para la Investigación Científica y Tecnológica
ID : PICT2016-1084
Organisme : Fondo para la Investigación Científica y Tecnológica
ID : PICT2017-3196
Organisme : Fondo para la Investigación Científica y Tecnológica
ID : PICT2019-3054
Organisme : Conicet
ID : PUE105
Organisme : The National Qatar Research Foundation
ID : NPRP13S-0209-200315
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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