Immunogenetic clustering of 30 cancers.

Alleles Cluster Analysis Female Gene Frequency Genetic Predisposition to Disease HLA Antigens / genetics Humans Immunogenetics Uterine Cervical Neoplasms / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
04 05 2022
Historique:
received: 27 01 2022
accepted: 15 04 2022
entrez: 4 5 2022
pubmed: 5 5 2022
medline: 7 5 2022
Statut: epublish

Résumé

Human leukocyte antigen (HLA) genes have been implicated in cancer risk and shared heritability of different types of cancer. In this immunogenetic epidemiological study we first computed a Cancer-HLA profile for 30 cancer types characterized by the correlation between the prevalence of each cancer and the population frequency of 127 HLA alleles, and then used multidimensional scaling to evaluate the possible clustering of those Cancer-HLA associations. The results indicated the presence of three clusters, broadly reflecting digestive-skin-cervical cancers, reproductive and endocrine systems cancers, and brain and androgen-associated cancers. The clustering of cancer types documented here is discussed in terms of mechanisms underlying shared Cancer-HLA associations.

Identifiants

DOI: 10.1038/s41598-022-11366-7 PMID: 35508592 PMC: PMC9068692
pubmed: 35508592
doi: 10.1038/s41598-022-11366-7
pii: 10.1038/s41598-022-11366-7
pmc: PMC9068692
doi:

Substances chimiques

HLA Antigens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

7235

Informations de copyright

© 2022. The Author(s).

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Auteurs

Lisa M James (LM)

The HLA Research Group, Brain Sciences Center (11B), Department of Veterans Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, MN, 55417, USA.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.

Apostolos P Georgopoulos (AP)

The HLA Research Group, Brain Sciences Center (11B), Department of Veterans Affairs Health Care System, Minneapolis VAHCS, One Veterans Drive, Minneapolis, MN, 55417, USA. omega@umn.edu.
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. omega@umn.edu.
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. omega@umn.edu.
Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. omega@umn.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de regroupements › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Immunogénétique › Immunogenetic clustering of 30 cancers.
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de l'utérus › Tumeurs du col de l'utérus › Immunogenetic clustering of 30 cancers.