Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
10 05 2022
Historique:
entrez: 5 5 2022
pubmed: 6 5 2022
medline: 10 5 2022
Statut: ppublish

Résumé

SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development.

Identifiants

pubmed: 35512094
doi: 10.1073/pnas.2202439119
pmc: PMC9171807
doi:

Substances chimiques

Antibodies, Monoclonal 0
GPI-Linked Proteins 0
Receptors, Chimeric Antigen 0
Mesothelin J27WDC343N

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2202439119

Subventions

Organisme : NIGMS NIH HHS
ID : R24 GM137782
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : S10OD018530
Organisme : HHS | National Institutes of Health (NIH)
ID : R24GM137782

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Auteurs

Xiufen Liu (X)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Masanori Onda (M)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Nathan Watson (N)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Raffit Hassan (R)

Thoracic and GI Malignancies Branch, NCI, Bethesda, MD 20892.

Mitchell Ho (M)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Tapan K Bera (TK)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Junxia Wei (J)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Anirban Chakraborty (A)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Richard Beers (R)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Qi Zhou (Q)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

Asif Shajahan (A)

Analytical Services and Training, University of Georgia, Athens, GA 30602-4712.

Parastoo Azadi (P)

Analytical Services and Training, University of Georgia, Athens, GA 30602-4712.

Jingyu Zhan (J)

Laboratory of Cell Biology, NCI, Bethesda, MD 20892-4255.

Di Xia (D)

Laboratory of Cell Biology, NCI, Bethesda, MD 20892-4255.

Ira Pastan (I)

Laboratory of Molecular Biology, National Cancer Institute (NCI), Bethesda, MD 20892-4264.

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Classifications MeSH