Chronic Lung Allograft Dysfunction.

Allografts Bronchiolitis Obliterans / etiology Chronic Disease Graft Rejection Humans Lung Lung Transplantation / adverse effects Primary Graft Dysfunction / etiology Retrospective Studies
BOS CLAD PPFE RAS

Journal

Thoracic surgery clinics
ISSN: 1558-5069
Titre abrégé: Thorac Surg Clin
Pays: United States
ID NLM: 101198195

Informations de publication

Date de publication:
May 2022
Historique:
entrez: 5 5 2022
pubmed: 6 5 2022
medline: 10 5 2022
Statut: ppublish

Résumé

Chronic lung allograft dysfunction (CLAD) is a syndrome of progressive lung function decline, subcategorized into obstructive, restrictive, and mixed phenotypes. The trajectory of CLAD is variable depending on the phenotype, with restrictive and mixed phenotypes having more rapid progression and lower survival. The mechanisms driving CLAD development remain unclear, though allograft injury during primary graft dysfunction, acute cellular rejection, antibody-mediated rejection, and infections trigger immune responses with long-lasting effects that can lead to CLAD months or years later. Currently, retransplantation is the only effective treatment.

Identifiants

DOI: 10.1016/j.thorsurg.2021.11.004 PMID: 35512941
pubmed: 35512941
pii: S1547-4127(21)00118-3
doi: 10.1016/j.thorsurg.2021.11.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

231-242

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure A. Venado: Pirfenidone for Restrictive Chronic Lung Allograft Dysfunction (PIRCLAD) study sponsored by Genentech (Principal Investigator). J. Kukreja: Lung Bioengineering (Data Safety Monitoring committee); Transmedics (research). John Greenland: Scientific Advisory Board for Atara Biotherapeutics, Theravance Biopharma, Boehringer Ingelheim; Research funding: Theravance Biopharma.

Auteurs

Aida Venado (A)

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, 505 Parnassus Ave, M1093A, San Francisco, CA 94143-2204, USA. Electronic address: aida.venado@ucsf.edu.

Jasleen Kukreja (J)

Division of Cardiothoracic Surgery, Univeristy of California, San Francisco, 500 Parnassus Ave, MU 405W Suite 305, San Francisco, CA 94143, USA.

John R Greenland (JR)

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, SF VAHCS Building 2, Room 453 (Mail stop 111D), 4150 Clement St, San Francisco CA 94121, USA.

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Classifications MeSH

questionsmedicales.fr › Régions du corps › Transplants › Allogreffes › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Bronchopneumopathies obstructives › Bronchiolite oblitérante › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › Appareil respiratoire › Poumon › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Transplantation pulmonaire › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › Dysfonction primaire du greffon › Chronic Lung Allograft Dysfunction.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Chronic Lung Allograft Dysfunction.