Feeding behavior elicited by mu opioid and GABA receptor activation in the lateral septum.
Eating
Feeding behavior
GABA
Lateral septum
Opioids
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
03
11
2021
revised:
22
04
2022
accepted:
28
04
2022
pubmed:
6
5
2022
medline:
15
6
2022
entrez:
5
5
2022
Statut:
ppublish
Résumé
The lateral septum (LS), a brain region typically associated with behaviors involving reward, anxiety-like behavior, learning, and memory, has recently received increased interest due to its potential role in eating behavior. Our current results showed that morphine (5 μg) microinjected into the LS produced a stable feeding response. Specifically, across five days of repeated injections, there was no increase or sensitization effect, nor a decrease in feeding or tolerance. Additionally, we found that pretreatment with the broad-spectrum opioid receptor antagonist naloxone blocked morphine-elicited feeding, further supporting a role for LS opioid receptors in the activation of feeding behaviors. We had previously found that the GABA
Identifiants
pubmed: 35513120
pii: S0091-3057(22)00074-0
doi: 10.1016/j.pbb.2022.173395
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
GABA-A Receptor Agonists
0
Receptors, GABA
0
Receptors, GABA-A
0
Receptors, Opioid
0
Receptors, Opioid, mu
0
Muscimol
2763-96-4
Morphine
76I7G6D29C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
173395Informations de copyright
Copyright © 2021. Published by Elsevier Inc.