ORCA, a values-based decision aid for selecting additional findings from genomic sequencing in adults: Efficacy results from a randomized trial.
Decision aid
Genomic sequencing
Incidental results
Informed consent
Secondary findings
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
ISSN: 1530-0366
Titre abrégé: Genet Med
Pays: United States
ID NLM: 9815831
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
05
10
2021
revised:
04
04
2022
accepted:
05
04
2022
pubmed:
7
5
2022
medline:
11
8
2022
entrez:
6
5
2022
Statut:
ppublish
Résumé
Individuals having genomic sequencing can choose to be notified about pathogenic variants in genes unrelated to the testing indication. A decision aid can facilitate weighing one's values before making a choice about these additional results. We conducted a randomized trial (N = 231) comparing informed values-choice congruence among adults at risk for a hereditary cancer syndrome who viewed either the Optional Results Choice Aid (ORCA) or web-based additional findings information alone. ORCA is values-focused with a low-literacy design. Individuals in both arms had informed values-choice congruence (75% and 73% in the decision aid and web-based groups, respectively; odds ratio [OR] = 1.10, 95% CI = 0.58-2.08). Most participants had adequate knowledge (79% and 76% in the decision aid and web-based groups, respectively; OR = 1.20, 95% CI = 0.61-2.34), with no significant difference between groups. Most had information-seeking values (97% and 98% in the decision aid and web-based groups, respectively; OR = 0.59, 95% CI = 0.10-3.61) and chose to receive additional findings. The ORCA decision aid did not significantly improve informed values-choice congruence over web-based information in this cohort of adults deciding about genomic results. Both web-based approaches may be effective for adults to decide about receiving medically actionable additional results.
Identifiants
pubmed: 35522237
pii: S1098-3600(22)00725-0
doi: 10.1016/j.gim.2022.04.008
pmc: PMC9586129
mid: NIHMS1810472
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1664-1674Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM007454
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007292
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007307
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG007292
Pays : United States
Informations de copyright
Copyright © 2022 American College of Medical Genetics and Genomics. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of Interest All authors declare no conflicts of interest.
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