Pericardial effusion in giant cell arteritis is associated with increased inflammatory markers: a retrospective cohort study.
Giant cell arteritis
Horton’s disease
Pericardial effusion
Pericarditis
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
22
02
2022
accepted:
16
04
2022
pubmed:
8
5
2022
medline:
28
9
2022
entrez:
7
5
2022
Statut:
ppublish
Résumé
Giant cell arteritis (GCA) is the most frequent vasculitis affecting adults aged > 50 years. Cardiac involvement in GCA is considered rare, and only a few cases of pericarditis have been reported. The aim of this study was to determine the characteristics and prognosis of GCA patients suffering from pericardial involvement at diagnosis. We conducted a single-centre, retrospective chart review of patients with GCA in internal medicine departments (from 2000 to 2020). Patients were identified through a centralized hospital database. We retrospectively collected demographic, clinicobiological, histological, imaging, treatment and outcome data. Patients with pericardial effusion, defined as an effusion visible on the CT-scan performed at GCA diagnosis were compared to those without pericardial involvement. Among the 250 patients with GCA, 23 patients (9.2%) had pericardial effusion on CT-scan. The comparison between the groups revealed similar distribution of age, gender, cranial symptoms and ocular ischaemic complications. Patients with pericardial effusion had a higher frequency of weight loss. They also had lower haemoglobin levels and higher platelet levels (p = 0.006 and p = 0.002, respectively), and they more frequently had positive temporal artery biopsy. There were no differences concerning the treatment, relapses, follow-up duration or deaths. This case series sheds light on GCA as a cause of unexplained pericardial effusion or symptomatic pericarditis among adults aged > 50 years and elevated inflammatory biological markers. Fortunately, pericardial involvement is a benign GCA manifestation. In that context, the search for constitutional symptoms, cranial symptoms and associated signs of polymyalgia rheumatica is crucial for rapidly guiding GCA diagnosis.
Identifiants
pubmed: 35525874
doi: 10.1007/s00296-022-05137-w
pii: 10.1007/s00296-022-05137-w
doi:
Substances chimiques
Biomarkers
0
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2013-2018Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Li KJ, Semenov D, Turk M, Pope J (2021) A meta-analysis of the epidemiology of giant cell arteritis across time and space. Arthritis Res Ther 23:82. https://doi.org/10.1186/s13075-021-02450-w
doi: 10.1186/s13075-021-02450-w
pubmed: 33706808
pmcid: 7948334
Jennette JC, Falk RJ, Bacon PA et al (2013) 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 65:1–11. https://doi.org/10.1002/art.37715
doi: 10.1002/art.37715
pubmed: 23045170
Ciofalo A, Gulotta G, Iannella G et al (2019) Giant cell arteritis (GCA): pathogenesis, clinical aspects and treatment approaches. Curr Rheumatol Rev 15:259–268. https://doi.org/10.2174/1573397115666190227194014
doi: 10.2174/1573397115666190227194014
pubmed: 30827250
de Boysson H, Liozon E, Espitia O et al (2019) Different patterns and specific outcomes of large-vessel involvements in giant cell arteritis. J Autoimmun 103:102283. https://doi.org/10.1016/j.jaut.2019.05.011
doi: 10.1016/j.jaut.2019.05.011
pubmed: 31130367
Salvarani C, Cimino L, Macchioni P et al (2005) Risk factors for visual loss in an Italian population-based cohort of patients with giant cell arteritis. Arthritis Rheum 53:293–297. https://doi.org/10.1002/art.21075
doi: 10.1002/art.21075
pubmed: 15818722
de Boysson H, Daumas A, Vautier M et al (2018) Large-vessel involvement and aortic dilation in giant-cell arteritis. A multicenter study of 549 patients. Autoimmun Rev 17:391–398. https://doi.org/10.1016/j.autrev.2017.11.029
doi: 10.1016/j.autrev.2017.11.029
pubmed: 29427822
Hellmich B, Agueda A, Monti S et al (2020) 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis 79:19–30. https://doi.org/10.1136/annrheumdis-2019-215672
doi: 10.1136/annrheumdis-2019-215672
pubmed: 31270110
Hunder GG, Bloch DA, Michel BA et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128. https://doi.org/10.1002/art.1780330810
doi: 10.1002/art.1780330810
pubmed: 2202311
Daumas A, Rossi P, Jacquier A, Granel B (2012) Myopericarditis revealing giant cell arteritis in the elderly. J Rheumatol 39:665–666. https://doi.org/10.3899/jrheum.110934
doi: 10.3899/jrheum.110934
pubmed: 22383362
Stanley D, Henderson D, Harris S (1991) Giant cell arteritis associated with pericarditis and large vessel disease. Aust N Z J Med 21:353–355. https://doi.org/10.1111/j.1445-5994.1991.tb04707.x
doi: 10.1111/j.1445-5994.1991.tb04707.x
pubmed: 1953518
Zenone T, Puget M (2014) Pericardial effusion and giant cell arteritis. Rheumatol Int 34:1465–1469. https://doi.org/10.1007/s00296-014-2958-6
doi: 10.1007/s00296-014-2958-6
pubmed: 24531736
Guindon A, Rossi P, Bagneres D et al (2007) Pericarditis: a giant cell arteritis manifestation. Rev Med Interne 28:326–331. https://doi.org/10.1016/j.revmed.2007.01.023
doi: 10.1016/j.revmed.2007.01.023
pubmed: 17335942
Georgakopoulou VE, Mermigkis D, Kairi O et al (2020) Simultaneous pleural and pericardial effusion as first clinical manifestations of giant cell arteritis: a case report. Cureus 12:e10163. https://doi.org/10.7759/cureus.10163
doi: 10.7759/cureus.10163
pubmed: 33014658
pmcid: 7526968
Teixeira A, Capitaine E, Congy F et al (2003) Myopericarditis during Horton disease. Rev Med Interne 24:189–194. https://doi.org/10.1016/s0248-8663(02)00809-3
doi: 10.1016/s0248-8663(02)00809-3
pubmed: 12657441
Moulis G, Sailler L, Astudillo L et al (2010) Pericarditis as the presenting manifestation of giant cell arteritis. Rev Med Interne 31:46–48. https://doi.org/10.1016/j.revmed.2009.05.005
doi: 10.1016/j.revmed.2009.05.005
pubmed: 19892444
Bablekos GD, Michaelides SA, Karachalios GN et al (2006) Pericardial involvement as an atypical manifestation of giant cell arteritis: report of a clinical case and literature review. Am J Med Sci 332:198–204. https://doi.org/10.1097/00000441-200610000-00007
doi: 10.1097/00000441-200610000-00007
pubmed: 17031245
Gómez-Barrado N, Polo Ostáriz MA, Aguilar Escobar J, Montes Ramírez JM (2000) Pericardial effusion as presentation form of giant cell arteritis. Rev Esp Cardiol 53:761. https://doi.org/10.1016/s0300-8932(00)75153-0
doi: 10.1016/s0300-8932(00)75153-0
pubmed: 10896570
Nicolás Sánchez FJ, Torres Cortada G, Sarrat Nuevo RM et al (2006) Pericarditis and giant cell arteritis. An Med Interna 23:382–384. https://doi.org/10.4321/s0212-71992006000800007
doi: 10.4321/s0212-71992006000800007
pubmed: 17067245
Nair JR, Somauroo JD, Over KE (2012) Myopericarditis in giant cell arteritis: case report of diagnostic dilemma and review of literature. Case Rep. https://doi.org/10.1136/bcr.12.2011.5469
doi: 10.1136/bcr.12.2011.5469
Manuel Cruz J, Santos C (2000) Afección pleuropericárdica en la arteritis de células gigantes. Med Clin 114:792. https://doi.org/10.1016/S0025-7753(00)71441-2
doi: 10.1016/S0025-7753(00)71441-2
Pant I, Smith A, Thomas T, Aiyappan V (2013) A woman with progressive lethargy and sudden onset of shortness of breath. Clin Med 13:625–627. https://doi.org/10.7861/clinmedicine.13-6-625
doi: 10.7861/clinmedicine.13-6-625
Konstantinou F, Vallianou N, Gennimata V et al (2020) A case report of pericardial effusion in giant cell arteritis. EJMCR. https://doi.org/10.24911/ejmcr/173-1558113081
doi: 10.24911/ejmcr/173-1558113081
Tiosano S, Adler Y, Azrielant S et al (2018) Pericarditis among giant cell arteritis patients: from myth to reality. Clin Cardiol 41:623–627. https://doi.org/10.1002/clc.22927
doi: 10.1002/clc.22927
pubmed: 29746000
pmcid: 6490016
Granel B, Serratrice J, Chaudier B et al (2001) Multinodular goitre with giant cell vasculitis of thyroid arteries in a woman with temporal arteritis. Ann Rheum Dis 60:811–812. https://doi.org/10.1136/ard.60.8.811a
doi: 10.1136/ard.60.8.811a
pubmed: 11482308
pmcid: 1753801
McKendry RJ, Guindi M, Hill DP (1990) Giant cell arteritis (temporal arteritis) affecting the breast: report of two cases and review of published reports. Ann Rheum Dis 49:1001–1004. https://doi.org/10.1136/ard.49.12.1001
doi: 10.1136/ard.49.12.1001
pubmed: 2270958
pmcid: 1004297
Theunissen P, Kliffen M, Dees A (2018) Giant-cell arteritis of the ovarian arteries: a rare manifestation of a common disease. Eur J Case Rep Intern Med 5:000779. https://doi.org/10.12890/2018_000779
doi: 10.12890/2018_000779
pubmed: 30756029
pmcid: 6346925
Deng J, Younge BR, Olshen RA et al (2010) Th17 and Th1 T-cell responses in giant cell arteritis. Circulation 121:906–915. https://doi.org/10.1161/CIRCULATIONAHA.109.872903
doi: 10.1161/CIRCULATIONAHA.109.872903
pubmed: 20142449
pmcid: 2837465
Lopalco G, Rigante D, Cantarini L et al (2021) The autoinflammatory side of recurrent pericarditis: Enlightening the pathogenesis for a more rational treatment. Trends Cardiovasc Med 31:265–274. https://doi.org/10.1016/j.tcm.2020.04.006
doi: 10.1016/j.tcm.2020.04.006
pubmed: 32376492