Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer.
Calcium signaling
Colorectal cancer
Curcumin
Mitochondria
NCLX
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
08 May 2022
08 May 2022
Historique:
received:
31
01
2022
accepted:
15
04
2022
revised:
05
04
2022
entrez:
8
5
2022
pubmed:
9
5
2022
medline:
11
5
2022
Statut:
epublish
Résumé
Recent evidences highlight a role of the mitochondria calcium homeostasis in the development of colorectal cancer (CRC). To overcome treatment resistance, we aimed to evaluate the role of the mitochondrial sodium-calcium-lithium exchanger (NCLX) and its targeting in CRC. We also identified curcumin as a new inhibitor of NCLX. We examined whether curcumin and pharmacological compounds induced the inhibition of NCLX-mediated mitochondrial calcium (mtCa In vitro, curcumin exerted strong anti-tumoral activity through its action on NCLX with mtCa Our findings highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic schedule of patients with MSI CRC.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Recent evidences highlight a role of the mitochondria calcium homeostasis in the development of colorectal cancer (CRC). To overcome treatment resistance, we aimed to evaluate the role of the mitochondrial sodium-calcium-lithium exchanger (NCLX) and its targeting in CRC. We also identified curcumin as a new inhibitor of NCLX.
METHODS
METHODS
We examined whether curcumin and pharmacological compounds induced the inhibition of NCLX-mediated mitochondrial calcium (mtCa
RESULTS
RESULTS
In vitro, curcumin exerted strong anti-tumoral activity through its action on NCLX with mtCa
CONCLUSIONS
CONCLUSIONS
Our findings highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic schedule of patients with MSI CRC.
Identifiants
pubmed: 35526196
doi: 10.1007/s00018-022-04311-4
pii: 10.1007/s00018-022-04311-4
doi:
Substances chimiques
Mitochondrial Proteins
0
Sodium-Calcium Exchanger
0
Curcumin
IT942ZTH98
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
284Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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