Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [
13C hyperpolarization
bSSFP
human clinical study
metabolism imaging
perfusion imaging
urea
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
22
03
2022
received:
08
02
2022
accepted:
23
03
2022
pubmed:
9
5
2022
medline:
1
7
2022
entrez:
8
5
2022
Statut:
ppublish
Résumé
This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized A metabolite-specific bSSFP urea imaging sequence was designed using a urea-specific excitation pulse, optimized TR, and 3D stack-of-spiral readouts. Simulations and phantom studies were performed to validate the spectral response of the sequence. The image quality of urea data acquired by the 3D-bSSFP sequence and the 2D-GRE sequence was evaluated with 2 identical injections of co-hyperpolarized [1- Simulations and phantom studies demonstrated that 3D-bSSFP sequence achieved urea-only excitation, while minimally perturbing other metabolites (<1%). An animal study demonstrated that compared to GRE, bSSFP sequence provided an ∼2.5-fold improvement in SNR without perturbing urea or pyruvate kinetics, and bSSFP approach with a shorter spiral readout reduced blurring artifacts caused by J-coupling of [ The 3D-bSSFP urea sequence with a stack-of-spiral acquisition demonstrated significantly increased SNR and image quality for [
Identifiants
pubmed: 35526263
doi: 10.1002/mrm.29266
pmc: PMC9810116
mid: NIHMS1850420
doi:
Substances chimiques
Pyruvic Acid
8558G7RUTR
Urea
8W8T17847W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1039-1054Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB013598
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK130002
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA249909
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA118816
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214554
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211150
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA232320
Pays : United States
Informations de copyright
© 2022 International Society for Magnetic Resonance in Medicine.
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