Fibrillin-1 regulates white adipose tissue development, homeostasis, and function.
Adipocyte differentiation
Adipose tissue
Extracellular matrix
Fibrillin-1
Marfan syndrome
Microfibrils
Journal
Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
18
11
2021
revised:
12
04
2022
accepted:
04
05
2022
pubmed:
10
5
2022
medline:
16
6
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
Fibrillin-1 is an extracellular glycoprotein present throughout the body. Mutations in fibrillin-1 cause a wide spectrum of type I fibrillinopathies, including Marfan syndrome characterized by clinical manifestations in adipose tissues, among others. This study addresses the hypothesis that fibrillin-1 regulates adipocyte development and plays a vital role in adipose tissue homeostasis. We employed two mouse models - Fbn1
Identifiants
pubmed: 35533973
pii: S0945-053X(22)00068-3
doi: 10.1016/j.matbio.2022.05.002
pii:
doi:
Substances chimiques
Fbn1 protein, mouse
0
Fibrillin-1
0
Fibrillin-2
0
Fibrillins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-128Subventions
Organisme : CIHR
ID : MOP-137091
Pays : Canada
Organisme : CIHR
ID : PJT-162099
Pays : Canada
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.