What Drives Radical Halogenation versus Hydroxylation in Mononuclear Nonheme Iron Complexes? A Combined Experimental and Computational Study.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
22 06 2022
Historique:
pubmed: 11 5 2022
medline: 24 6 2022
entrez: 10 5 2022
Statut: ppublish

Résumé

Nonheme iron halogenases are unique enzymes in nature that selectively activate an aliphatic C-H bond of a substrate to convert it into C-X (X = Cl/Br, but not F/I). It is proposed that they generate an Fe

Identifiants

pubmed: 35537044
doi: 10.1021/jacs.2c01375
pmc: PMC9228086
mid: NIHMS1802621
doi:

Substances chimiques

Halogens 0
Carbon 7440-44-0
Iron E1UOL152H7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

10752-10767

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM119374
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011208/1
Pays : United Kingdom

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Auteurs

Emilie F Gérard (EF)

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

Vishal Yadav (V)

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

David P Goldberg (DP)

Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

Sam P de Visser (SP)

Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.
Department of Chemical Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

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Classifications MeSH