Hydroxylamine-induced oxidation of ferrous nitrobindins.
Ferrous Arabidopsis thaliana nitrobindin
Ferrous Homo sapiens nitrobindin
Ferrous Mycobacterium tuberculosis nitrobindin
Hydroxylamine-induced oxidation
Kinetics
Journal
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
ISSN: 1432-1327
Titre abrégé: J Biol Inorg Chem
Pays: Germany
ID NLM: 9616326
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
20
12
2021
accepted:
21
04
2022
pubmed:
12
5
2022
medline:
26
8
2022
entrez:
11
5
2022
Statut:
ppublish
Résumé
Hemoglobin and myoglobin are generally taken as molecular models of all-α-helical heme-proteins. On the other hand, nitrophorins and nitrobindins (Nb), which are arranged in 8 and 10 β-strands, respectively, represent the molecular models of all-β-barrel heme-proteins. Here, kinetics of the hydroxylamine- (HA-) mediated oxidation of ferrous Mycobacterium tuberculosis, Arabidopsis thaliana, and Homo sapiens nitrobindins (Mt-Nb(II), At-Nb(II), and Hs-Nb(II), respectively), at pH 7.0 and 20.0 °C, are reported. Of note, HA displays antibacterial properties and is a good candidate for the treatment and/or prevention of reactive nitrogen species- (RNS-) linked aging-related pathologies, such as macular degeneration. Under anaerobic conditions, mixing the Mt-Nb(II), At-Nb(II), and Hs-Nb(II) solutions with the HA solutions brings about absorbance spectral changes reflecting the formation of the ferric derivative (i.e., Mt-Nb(III), At-Nb(III), and Hs-Nb(III), respectively). Values of the second order rate constant for the HA-mediated oxidation of Mt-Nb(II), At-Nb(II), and Hs-Nb(II) are 1.1 × 10
Identifiants
pubmed: 35543759
doi: 10.1007/s00775-022-01940-9
pii: 10.1007/s00775-022-01940-9
doi:
Substances chimiques
Ferric Compounds
0
Hydroxylamines
0
Myoglobin
0
Hydroxylamine
2FP81O2L9Z
Heme
42VZT0U6YR
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-453Informations de copyright
© 2022. The Author(s), under exclusive licence to Society for Biological Inorganic Chemistry (SBIC).
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