Negative Ultraselection of Patients With


Journal

JCO precision oncology
ISSN: 2473-4284
Titre abrégé: JCO Precis Oncol
Pays: United States
ID NLM: 101705370

Informations de publication

Date de publication:
04 2022
Historique:
entrez: 11 5 2022
pubmed: 12 5 2022
medline: 18 5 2022
Statut: ppublish

Résumé

Several uncommon genomic alterations beyond A prospective data set at three Italian Academic Hospitals included 650 patients with mCRC with comprehensive genomic profiling by FoundationOne CDx and treated with anti-EGFRs. PRESSING2 panel alterations were selected on the basis of previous clinico-biologic studies and included Among 162 hyperselected patients, 24 (15%) had PRESSING2 alterations, which were mutually exclusive except in two samples and were numerically higher in right-sided versus left-sided cancers (28% Negative ultraselection warrants further investigation with the aim of maximizing the benefit of EGFR blockade strategies in patients with

Identifiants

pubmed: 35544729
doi: 10.1200/PO.22.00037
pmc: PMC9200389
doi:

Substances chimiques

ErbB Receptors EC 2.7.10.1
BRAF protein, human EC 2.7.11.1
Proto-Oncogene Proteins B-raf EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2200037

Commentaires et corrections

Type : ErratumIn

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Auteurs

Giovanni Randon (G)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Giulia Maddalena (G)

Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.
Department of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.

Marco Maria Germani (MM)

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Chiara Carlotta Pircher (CC)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Paolo Manca (P)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Francesca Bergamo (F)

Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.

Mirella Giordano (M)

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Caterina Sposetti (C)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Aldo Montagna (A)

Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.

Guglielmo Vetere (G)

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Luca Zambelli (L)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Cosimo Rasola (C)

Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy.

Alessandra Boccaccino (A)

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Filippo Pagani (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Margherita Ambrosini (M)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Marco Massafra (M)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Gabriella Fontanini (G)

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Massimo Milione (M)

First Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Matteo Fassan (M)

Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padova, Italy.
Veneto Institute of Oncology-IRCCS, Padova, Italy.

Chiara Cremolini (C)

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Sara Lonardi (S)

Oncology Unit 3, Veneto Institute of Oncology-IRCCS, Padova, Italy.

Filippo Pietrantonio (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

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