Flavanols from Tetrapleura tetraptera with cytotoxic activities.
Cytotoxicity
Fabaceae
Flavan-3,4-diols
Flavan-3-ol
Tetrapleura tetraptera
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
19
03
2022
revised:
04
05
2022
accepted:
04
05
2022
pubmed:
12
5
2022
medline:
22
6
2022
entrez:
11
5
2022
Statut:
ppublish
Résumé
Tetrapleura tetraptera is a medicinal plant used in East and West Africa to treat inflammation and related diseases. From the stem bark of the plant, three previously undescribed flavan-3-ol derivatives named (2R,3S)-3,3',5',7-tetrahydroxy-4'-methoxyflavane (1), (2R,3S)-3',5',7-trihydroxy-4'-methoxyflavane-3-O-β-D-glucopyranoside (2), and (2R,3S,4S)-3,3',4,5',7-pentahydroxy-4'-methoxyflavane (3) were isolated with three known analogues. The structural elucidation of the compounds was performed based on NMR spectroscopy and HRMS data analyses. The absolute configurations around the stereogenic carbons were determined using Circular Dichroism (ECD) and density functional theory (DFT) calculations. The cytotoxicity of the isolated compounds was tested using resazurin reduction assay. Compound 1 was moderately active against both recalcitrant leukemia cell lines with IC
Identifiants
pubmed: 35545131
pii: S0367-326X(22)00084-3
doi: 10.1016/j.fitote.2022.105206
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Polyphenols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105206Informations de copyright
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