Circulating virome and inflammatory proteome in patients with ST-elevation myocardial infarction and primary ventricular fibrillation.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 05 2022
12 05 2022
Historique:
received:
02
09
2021
accepted:
05
05
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Primary ventricular fibrillation (PVF) is a life-threatening complication of ST-segment elevation myocardial infarction (STEMI). It is unclear what roles viral infection and/or systemic inflammation may play as underlying triggers of PVF, as a second hit in the context of acute ischaemia. Here we aimed to evaluate whether the circulating virome and inflammatory proteome were associated with PVF development in patients with STEMI. Blood samples were obtained from non-PVF and PVF STEMI patients at the time of primary PCI, and from non-STEMI healthy controls. The virome profile was analysed using VirCapSeq-VERT (Virome Capture Sequencing Platform for Vertebrate Viruses), a sequencing platform targeting viral taxa of 342,438 representative sequences, spanning all virus sequence records. The inflammatory proteome was explored with the Olink inflammation panel, using the Proximity Extension Assay technology. After analysing all viral taxa known to infect vertebrates, including humans, we found that non-PVF and PVF patients only significantly differed in the frequencies of viruses in the Gamma-herpesvirinae and Anelloviridae families. In particular, most showed a significantly higher relative frequency in non-PVF STEMI controls. Analysis of systemic inflammation revealed no significant differences between the inflammatory profiles of non-PVF and PVF STEMI patients. Inflammatory proteins associated with cell adhesion, chemotaxis, cellular response to cytokine stimulus, and cell activation proteins involved in immune response (IL6, IL8 CXCL-11, CCL-11, MCP3, MCP4, and ENRAGE) were significantly higher in STEMI patients than non-STEMI controls. CDCP1 and IL18-R1 were significantly higher in PVF patients compared to healthy subjects, but not compared to non-PVF patients. The circulating virome and systemic inflammation were not associated with increased risk of PVF development in acute STEMI. Accordingly, novel strategies are needed to elucidate putative triggers of PVF in the setting of acute ischaemia, in order to reduce STEMI-driven sudden death burden.
Identifiants
pubmed: 35552514
doi: 10.1038/s41598-022-12075-x
pii: 10.1038/s41598-022-12075-x
pmc: PMC9098642
doi:
Substances chimiques
Antigens, Neoplasm
0
CDCP1 protein, human
0
Cell Adhesion Molecules
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7910Informations de copyright
© 2022. The Author(s).
Références
N Engl J Med. 2018 Jan 25;378(4):345-353
pubmed: 29365305
PLoS One. 2020 Feb 26;15(2):e0226936
pubmed: 32101559
JAMA. 2012 Sep 12;308(10):998-1006
pubmed: 22928184
Front Physiol. 2019 Oct 02;10:1215
pubmed: 31632285
Hum Pathol. 1999 Sep;30(9):1114-7
pubmed: 10492049
Atherosclerosis. 2006 May;186(1):140-5
pubmed: 16084515
Cytokine X. 2020 Oct 08;2(4):100037
pubmed: 33604561
Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):2047-52
pubmed: 20651278
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Circ Arrhythm Electrophysiol. 2012 Feb;5(1):237-43
pubmed: 22334431
PLoS One. 2014 Apr 22;9(4):e95192
pubmed: 24755770
PLoS One. 2017 Jan 13;12(1):e0170193
pubmed: 28085969
Eur Heart J. 2018 Jan 7;39(2):119-177
pubmed: 28886621
J Cardiol Cases. 2019 Dec 26;21(4):137-140
pubmed: 32256861
Virol J. 2013 Jun 11;10:191
pubmed: 23758761
Sci Total Environ. 2021 Jun 1;771:145436
pubmed: 33736166
J Am Coll Cardiol. 2006 Jul 18;48(2):287-92
pubmed: 16843177
Clin Sci (Lond). 2009 Jul 02;117(3):95-109
pubmed: 19566488
Immunol Invest. 2022 May;51(4):802-816
pubmed: 33522333
Eur Heart J. 2014 Jan;35(2):116-22
pubmed: 24258072
JACC Case Rep. 2020 May 20;2(5):756-759
pubmed: 34317342
J Am Coll Cardiol. 2014 Feb 18;63(6):549-59
pubmed: 24291282
J Cardiovasc Med (Hagerstown). 2011 Nov;12(11):843-7
pubmed: 22288081
Int J Mol Sci. 2020 Sep 08;21(18):
pubmed: 32911750
Lancet Infect Dis. 2009 Oct;9(10):601-10
pubmed: 19778762
Am J Infect Control. 2014 Aug;42(8):856-60
pubmed: 25087137
BMC Genomics. 2011 Nov 30;12 Suppl 3:S23
pubmed: 22369086
J Am Heart Assoc. 2020 Oct 20;9(20):e017159
pubmed: 33054490
J Am Coll Cardiol. 2018 Jul 10;72(2):187-198
pubmed: 29976293
Am J Cardiol. 2018 Aug 15;122(4):529-536
pubmed: 29960663
Circulation. 2002 Jun 4;105(22):2595-9
pubmed: 12045163
PLoS Med. 2021 Jan 13;18(1):e1003513
pubmed: 33439866
Stem Cells. 2007 Jan;25(1):245-51
pubmed: 17053210
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Nat Genet. 2010 Aug;42(8):688-691
pubmed: 20622880
Circulation. 2001 Jul 3;104(1):25-31
pubmed: 11435333
Clin Chem Lab Med. 2011 Jul;49(7):1237-9
pubmed: 21574885
Eur Heart J. 2012 Oct;33(20):2551-67
pubmed: 22922414
J Comput Biol. 2012 May;19(5):455-77
pubmed: 22506599
Exp Mol Pathol. 2009 Oct;87(2):127-32
pubmed: 19631640
J Am Coll Cardiol. 2007 Dec 4;50(23):2207-14
pubmed: 18061067
Clin Chem Lab Med. 2019 Jun 26;57(7):1093-1101
pubmed: 30707681
mBio. 2015 Sep 22;6(5):e01491-15
pubmed: 26396248
Nat Rev Cancer. 2016 Dec;16(12):789-802
pubmed: 27687982
BMC Bioinformatics. 2014 Jun 30;15:227
pubmed: 24976580
Circulation. 2009 Jun 9;119(22):2868-76
pubmed: 19470888
Catheter Cardiovasc Interv. 2013 Jul 1;82(1):E1-27
pubmed: 23299937
Resuscitation. 2020 Jul;152:165-169
pubmed: 32422242
J Cell Mol Med. 2020 Sep;24(17):10042-10051
pubmed: 32701210
BMJ Open. 2015 Dec 09;5(12):e009148
pubmed: 26656019
Transfusion. 2010 Nov;50(11):2474-83
pubmed: 20497515
Int J Cardiol. 2018 Jul 15;263:158-162
pubmed: 29754914
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Eur Heart J Acute Cardiovasc Care. 2020 Nov;9(4_suppl):S161-S168
pubmed: 30175597
Immunity. 1996 Aug;5(2):173-9
pubmed: 8769480
J Med Virol. 2018 Dec;90(12):1814-1821
pubmed: 30011073
Atherosclerosis. 2004 Jul;175(1):91-4
pubmed: 15186951