Free water diffusion MRI and executive function with a speed component in healthy aging.
Aging
Cognitive speed
Corpus callosum
Executive functions
Fornix
Free water diffusion
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
01
03
2022
revised:
06
05
2022
accepted:
09
05
2022
pubmed:
15
5
2022
medline:
22
6
2022
entrez:
14
5
2022
Statut:
ppublish
Résumé
Extracellular free water (FW) increases are suggested to better provide pathophysiological information in brain aging than conventional biomarkers such as fractional anisotropy. The aim of the present study was to determine the relationship between conventional biomarkers, FW in white matter hyperintensities (WMH), FW in normal appearing white matter (NAWM) and in white matter tracts and executive functions (EF) with a speed component in elderly persons. We examined 226 healthy elderly participants (median age 69.83 years, IQR: 56.99-74.42) who underwent brain MRI and neuropsychological examination. FW in WMH and in NAWM as well as FW corrected diffusion metrics and measures derived from conventional MRI (white matter hyperintensities, brain volume, lacunes) were used in partial correlation (adjusted for age) to assess their correlation with EF with a speed component. Random forest analysis was used to assess the relative importance of these variables as determinants. Lastly, linear regression analyses of FW in white matter tracts corrected for risk factors of cognitive and white matter deterioration, were used to examine the role of specific tracts on EF with a speed component, which were then ranked with random forest regression. Partial correlation analyses revealed that almost all imaging metrics showed a significant association with EF with a speed component (r = -0.213 - 0.266). Random forest regression highlighted FW in WMH and in NAWM as most important among all diffusion and structural MRI metrics. The fornix (R
Identifiants
pubmed: 35568345
pii: S1053-8119(22)00422-0
doi: 10.1016/j.neuroimage.2022.119303
pmc: PMC9465649
mid: NIHMS1832292
pii:
doi:
Substances chimiques
Biomarkers
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119303Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015902
Pays : United States
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declarations of Competing Interest None.
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