Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice.
ALZHEIMER'S DISEASE
BONE FRAGILITY
MUSCLE
OSTEOCLAST
TREM2
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
25
04
2022
received:
03
12
2021
accepted:
11
05
2022
pubmed:
17
5
2022
medline:
15
7
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Previous studies proposed the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a receptor expressed in myeloid cells including microglia in brain and osteoclasts in bone, as a link between brain and bone disease. The TREM2 R47H variant is a known risk factor for Alzheimer's disease (AD), the most common form of dementia. To investigate whether altered TREM2 signaling could contribute to bone and skeletal muscle loss, independently of central nervous system defects, we used mice globally hemizygous for the TREM2 R47H variant (TREM2
Identifiants
pubmed: 35575023
doi: 10.1002/jbmr.4572
pmc: PMC9307075
mid: NIHMS1808283
doi:
Substances chimiques
Estrogens
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
Trem2 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1366-1381Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR079379
Pays : United States
Organisme : BLRD VA
ID : I01 BX005154
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM077229
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR065971
Pays : United States
Informations de copyright
© 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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